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Art. -Nr.: HY-170565

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CHD-1

CHD-1 is a a hypoxia-activated antitumor prodrug. CHD-1 impairs mitochondrial morphology and membrane potential in hypoxic tumor cells, further triggering excessive mitophagy and inducing apoptosis. CHD-1 inhibits the growth of hypoxic tumor cells in vitro and the growth of HeLa xenograft in vivo.

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CAS. Nr.: 3041166-70-2
Formel: C₁₆H₁₂FNO₄
Molecular Weight:301.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

CHD-1 Chemical Structure

CAS. Nr.: 3041166-70-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: CHD-1	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs	[PMID: 36610249]
HCT-116	IC₅₀	>50 μM Compound: CHD-1	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs	[PMID: 36610249]
HeLa	IC₅₀	>50 μM Compound: CHD-1	Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs Cytotoxicity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs	[PMID: 36610249]
HepG2	IC₅₀	>50 μM Compound: CHD-1	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs	[PMID: 36610249]
MCF7	IC₅₀	>100 μM Compound: CHD-1	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs	[PMID: 36610249]

Chemical Information

CAS. Nr. 3041166-70-2
Molecular Weight 301.27
Formel C₁₆H₁₂FNO₄
SMILES

FC1=CC(C(/C=C/C2=CC=CC([N+]([O-])=O)=C2)=O)=CC=C1OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang F, et al. Hypoxia-selective prodrug restrains tumor cells through triggering mitophagy and inducing apoptosis. Eur J Med Chem. 2025 Feb 5;283:117155. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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