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Art. -Nr.: HY-19251

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CL-283796

CL-283796 is a potent and orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. CL-283796 reduces low-density lipoprotein (LDL) cholesterol without affecting cholesterol absorption in African green monkeys. CL-283796 can be used for hypercholesterolemia research.

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CAS. Nr.: 107376-72-7
Formel: C₂₈H₄₁ClN₂O
Molecular Weight:457.09

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CL-283796 Chemical Structure

CAS. Nr.: 107376-72-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

ACAT

Alle Acyltransferase Isoform-spezifische Produkte anzeigen :

In Vivo

CL-283796 (p.o., 10 mg/kg daily for 5 weeks and 30 mg/kg daily for the next 5 weeks) reduces LDL cholesterol without affecting cholesterol absorption in African green monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult African green monkeys fed an atherogenic diet for approximately 6 weeks^[1]
Dosage:

10 and 30 mg/kg
Administration:

p.o., 10 mg/kg daily for 5 weeks and 30 mg/kg daily for the next 5 weeks
Result:

Resulted in a 24.1% reduction in total plasma cholesterol after 30 days (10 mg/kg dose).
Resulted in significant reductions in LDL cholesterol but non-significant effects on VLDL cholesterol values.
Showed no significant effects on plasma triglyceride values, HDL cholesterol, and apolipoproteins A-I, B and E levels.
Decreased the total plasma cholesterol (TPC)/HDL cholesterol ratios by 40% after 10 weeks.
Showed no significant effect on cholesterol absorption.
Did not affect body weights.

Chemical Information

CAS. Nr. 107376-72-7
Molecular Weight 457.09
Formel C₂₈H₄₁ClN₂O
SMILES

O=C(NC1=C(C)C=C(Cl)C=C1C)N(CCCCCCC)CC2=CC=C(CCC(C)C)C=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wrenn SM Jr, et al. ACAT inhibitors CL 283,546 and CL 283,796 reduce LDL cholesterol without affecting cholesterol absorption in African green monkeys. J Lipid Res. 1995 Jun;36(6):1199-210. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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CL-283796

Alle Acyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CL-283796 Related Classifications

HY-19251 Related Classifications