Claficapavir
Based on 1 Customer Validation
Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1.
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- Reinheit : 98.75%
- CAS. Nr.: 2055732-24-4
- Formel: C17H12ClNO4S2
- Molecular Weight:393.86
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
HIV-1 |
In Vitro
Claficapavir binds directly to HIV-1 NC, thereby inhibiting specific chaperone functions of NC including Psi RNA dimerization and complementary trans-activation response element (cTAR) DNA destabilization, and it also disrupts the proper Gag processing[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2055732-24-4
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Appearance Solid
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Molecular Weight 393.86
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Formel C17H12ClNO4S2
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Color Yellow to orange
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SMILES
O=C(N(C(S/1)=S)CCC(O)=O)C1=C\C2=CC=C(C3=CC=C(C=C3)Cl)O2
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Synonyms
A1752
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 200 mg/mL (507.79 mM; ultrasonic and warming and heat to 40°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5390 mL | 12.6949 mL | 25.3897 mL | 63.4743 mL |
| 5 mM | 0.5078 mL | 2.5390 mL | 5.0779 mL | 12.6949 mL | |
| 10 mM | 0.2539 mL | 1.2695 mL | 2.5390 mL | 6.3474 mL | |
| 15 mM | 0.1693 mL | 0.8463 mL | 1.6926 mL | 4.2316 mL | |
| 20 mM | 0.1269 mL | 0.6347 mL | 1.2695 mL | 3.1737 mL | |
| 25 mM | 0.1016 mL | 0.5078 mL | 1.0156 mL | 2.5390 mL | |
| 30 mM | 0.0846 mL | 0.4232 mL | 0.8463 mL | 2.1158 mL | |
| 40 mM | 0.0635 mL | 0.3174 mL | 0.6347 mL | 1.5869 mL | |
| 50 mM | 0.0508 mL | 0.2539 mL | 0.5078 mL | 1.2695 mL | |
| 60 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0579 mL | |
| 80 mM | 0.0317 mL | 0.1587 mL | 0.3174 mL | 0.7934 mL | |
| 100 mM | 0.0254 mL | 0.1269 mL | 0.2539 mL | 0.6347 mL |
Claficapavir Related Classifications
HY-145560 Related Classifications
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