Cyclapolin 9
Based on 1 Customer Validation
Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases.
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- Reinheit : 98.09%
- CAS. Nr.: 40533-25-3
- Formel: C9H4F3N3O4S
- Molecular Weight:307.21
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[2]|
PLK1 500 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
24.8 μM
Compound: cyclapolin 9
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Cytotoxicity against human A549 cells assessed as mitotic progression after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as mitotic progression after 72 hrs by MTT assay
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[PMID: 17028581] |
| HeLa | IC50 |
6.6 μM
Compound: cyclapolin 9
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Cytotoxicity against human HeLa cells assessed as mitotic progression after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as mitotic progression after 72 hrs by MTT assay
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[PMID: 17028581] |
| HT-29 | IC50 |
7.7 μM
Compound: cyclapolin 9
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Cytotoxicity against human HT-29 cells assessed as mitotic progression after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as mitotic progression after 72 hrs by MTT assay
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[PMID: 17028581] |
In Vitro
Cyclapolin 9 (3 μM) reduces electric field stimulation (EFS)-induced contractions of prostate strips. The α1-adrenergic smooth muscle contraction in the human prostate can be inhibited by Cyclapolin 9[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 40533-25-3
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Appearance Solid
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Molecular Weight 307.21
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Formel C9H4F3N3O4S
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Color Light yellow to yellow
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SMILES
O=C(C1=[N+]([O-])C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2S1)N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 20 mg/mL (65.10 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Martin Hennenberg, et al. Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases. Front Physiol. 2018 Jun 15;9:734. [Content Brief]
[2]. Campbell McInnes, et al. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2551 mL | 16.2755 mL | 32.5510 mL | 81.3776 mL |
| 5 mM | 0.6510 mL | 3.2551 mL | 6.5102 mL | 16.2755 mL | |
| 10 mM | 0.3255 mL | 1.6276 mL | 3.2551 mL | 8.1378 mL | |
| 15 mM | 0.2170 mL | 1.0850 mL | 2.1701 mL | 5.4252 mL | |
| 20 mM | 0.1628 mL | 0.8138 mL | 1.6276 mL | 4.0689 mL | |
| 25 mM | 0.1302 mL | 0.6510 mL | 1.3020 mL | 3.2551 mL | |
| 30 mM | 0.1085 mL | 0.5425 mL | 1.0850 mL | 2.7126 mL | |
| 40 mM | 0.0814 mL | 0.4069 mL | 0.8138 mL | 2.0344 mL | |
| 50 mM | 0.0651 mL | 0.3255 mL | 0.6510 mL | 1.6276 mL | |
| 60 mM | 0.0543 mL | 0.2713 mL | 0.5425 mL | 1.3563 mL |
Cyclapolin 9 Related Classifications
HY-15159 Related Classifications
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