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Art. -Nr.: HY-N19749

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Decumbensine

(Synonyms: (+)-Decumbensine; (+)-Egenine)

Decumbensine ((+)-Egenine) is a phthalideisoquinoline hemiacetal alkaloid present in Corydalis decumbens. Decumbensine significantly inhibits spontaneous calcium oscillations in primary cultured neocortical neurons, reducing oscillation frequency and amplitude. Decumbensine can be used in studies related to central nervous system diseases, epilepsy and pain.

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CAS. Nr.: 6883-44-9
Formel: C₂₀H₁₉NO₆
Molecular Weight:369.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Decumbensine Chemical Structure

CAS. Nr.: 6883-44-9

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Biologische Aktivität

Beschreibung

Decumbensine ((+)-Egenine) is a phthalideisoquinoline hemiacetal alkaloid present in Corydalis decumbens^[1]^[2]^[3]. Decumbensine significantly inhibits spontaneous calcium oscillations in primary cultured neocortical neurons, reducing oscillation frequency and amplitude^[2]. Decumbensine can be used in studies related to central nervous system diseases, epilepsy and pain^[1]^[2].

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In Vitro

Decumbensine (6.8 μM) potently inhibits spontaneous calcium oscillations in primary cultured neocortical neurons with an IC₅₀ of 6.8 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 6883-44-9
Molecular Weight 369.37
Formel C₂₀H₁₉NO₆
SMILES

CN1[C@](C2=C(CC1)C=C3C(OCO3)=C2)([H])[C@@]4([H])C5=C(C6=C(OCO6)C=C5)[C@H](O4)O
Synonyms

(+)-Decumbensine; (+)-Egenine
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhang JS,et al. Decumbensine and epi-α-Decumbensine: Two New Alkaloids Isolated from Corydalis decumbens. J Nat Prod. 1988 Nov-Dec;51(6):1241-1242.

[2]. Zhang CL,et al. Phthalideisoquinoline Hemiacetal Alkaloids from Corydalis decumbens That Inhibit Spontaneous Calcium Oscillations, Including Alkyl Derivatives of (+)-Egenine That Are Strikingly Levorotatory. J Nat Prod. 2019 Oct 25;82(10):2713-2720. [Content Brief]

[3]. Chang J,et al. Two novel isoquinoline alkaloids from the seedling of Corydalis decumbens. Tetrahedron Lett. 2015 Jan 1;56(1):225-228. doi: 10.1016/j.tetlet.2014.11.066.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Decumbensine

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Decumbensine Related Classifications

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