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Art. -Nr.: HY-Y0284

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Diethyl phthalate

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Diethyl phthalate is an orally active plasticizer and detergent base. Diethyl phthalate increases the activities of ACP, ALP, SDH, and ALT in liver, muscle, or both tissues. Diethyl phthalate induces dose-dependent mortality and sluggish behavior in freshwater fish. Diethyl phthalate may induce male reproductive toxicity. Diethyl phthalate is added to plastic polymers to help maintain their flexibility.

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Reinheit: 99.87%
CAS. Nr.: 84-66-2
Formel: C₁₂H₁₄O₄
Molecular Weight:222.24

Speicherung:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Diethyl phthalate Chemical Structure

CAS. Nr.: 84-66-2

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Aminotransferases (Transaminases) Isoform-spezifische Produkte anzeigen :

In Vivo

Diethyl phthalate (25-100 ppm; continuous/daily single aquatic exposure; 3 days-72 h) causes dose-dependent mortality in the fish species *Cirrhina mrigala*, with 100% mortality observed within 24 h at concentrations of 75 ppm and 100 ppm; exposure at 25 ppm also alters the activities of key metabolic and neurological enzymes^[1].
Diethyl phthalate (p.o.) mainly distributes in the kidneys and liver of rats, and subsequently accumulates in adipose tissue^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Cirrhina mrigala (65 mm length, 4 g weight, 6 fish per group)^[1]
Dosage:

25 ppm, 50 ppm, 75 ppm, 100 ppm (mortality assessment); 25 ppm (enzyme activity assays)
Administration:

aquatic exposure; continuous (mortality assessment); once daily; 3 days (enzyme activity assays)
Result:

Caused 100% mortality within 24 hours in fish exposed to 75 ppm and 100 ppm DEP.
Caused 50% mortality within 72 hours in fish exposed to 50 ppm DEP.
Caused 10% mortality within 72 hours in fish exposed to 25 ppm DEP, with remaining fish surviving the extended 3-day treatment.
Significantly increased liver and muscle acid phosphatase (ACP) and alkaline phosphatase (ALP) activity compared to controls in fish treated with 25 ppm DEP for 3 days.
Significantly increased muscle succinate dehydrogenase (SDH) activity compared to controls in fish treated with 25 ppm DEP for 3 days.
Significantly increased liver alanine aminotransferase (ALT) activity (nearly double) compared to controls in fish treated with 25 ppm DEP for 3 days.
Significantly decreased brain acetylcholinesterase (AchE) activity compared to controls in fish treated with 25 ppm DEP for 3 days.
Significantly increased liver aspartate aminotransferase (AST) activity compared to negative controls (though lower than positive controls) in fish treated with 25 ppm DEP for 3 days.
Showed no significant change in liver SDH activity compared to controls in fish treated with 25 ppm DEP for 3 days.
Showed no significant change in muscle AchE activity compared to controls in fish treated with 25 ppm DEP for 3 days.

Chemical Information

CAS. Nr. 84-66-2
Appearance Liquid (Density: 1.12 g/cm³)
Molecular Weight 222.24
Formel C₁₂H₁₄O₄
Color Colorless to light yellow
SMILES

O=C(C1=CC=CC=C1C(OCC)=O)OCC
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Sci Rep

Integrative network toxicology and experimental evidence reveal mechanisms underlying diethyl phthalate-induced initiation and progression of endometrial cancer. [Abstract]

2026 Feb 10;16(1):8066. PMID: 41667778
Food Chem Toxicol

Integrated network toxicology, molecular docking and transcriptomics reveal the mechanistic role of phthalate esters in metabolic disease pathogenesis. [Abstract]

2026 Jan:207:115855. PMID: 41275904

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 200 mg/mL (899.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.4996 mL

22.4982 mL

44.9964 mL

5 mM

0.8999 mL

4.4996 mL

8.9993 mL

10 mM

0.4500 mL

2.2498 mL

4.4996 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (762 KB)
- English - EN (762 KB)
- Français - FR (762 KB)
- Deutsch - DE (762 KB)
- Norwegian - NO (762 KB)
- Español - ES (762 KB)
- Swedish - SV (762 KB)
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- Korean - KR (762 KB)
- Portuguese - PT (762 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ghorpade N, et al. Toxicity study of diethyl phthalate on freshwater fish Cirrhina mrigala. Ecotoxicol Environ Saf. 2002;53(2):255-258. [Content Brief]

[2]. Weaver JA, et al. Hazards of diethyl phthalate (DEP) exposure: A systematic review of animal toxicology studies. Environ Int. 2020;145:105848. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.4996 mL	22.4982 mL	44.9964 mL	112.4910 mL
	5 mM	0.8999 mL	4.4996 mL	8.9993 mL	22.4982 mL
	10 mM	0.4500 mL	2.2498 mL	4.4996 mL	11.2491 mL
	15 mM	0.3000 mL	1.4999 mL	2.9998 mL	7.4994 mL
	20 mM	0.2250 mL	1.1249 mL	2.2498 mL	5.6245 mL
	25 mM	0.1800 mL	0.8999 mL	1.7999 mL	4.4996 mL
	30 mM	0.1500 mL	0.7499 mL	1.4999 mL	3.7497 mL
	40 mM	0.1125 mL	0.5625 mL	1.1249 mL	2.8123 mL
	50 mM	0.0900 mL	0.4500 mL	0.8999 mL	2.2498 mL
	60 mM	0.0750 mL	0.3750 mL	0.7499 mL	1.8748 mL
	80 mM	0.0562 mL	0.2812 mL	0.5625 mL	1.4061 mL
	100 mM	0.0450 mL	0.2250 mL	0.4500 mL	1.1249 mL

Diethyl phthalate

2 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Diethyl phthalate

Publications Citing Use of MedChemExpress (MCE) Diethyl phthalate

Alle Aminotransferases (Transaminases) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Diethyl phthalate Related Classifications

HY-Y0284 Related Classifications