Mapk9 - mitogen-activated protein kinase 9 Gene

Also Known as JNK2; Prkm9; p54aSAPK

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26420

About Mapk9

Chromosome 11: 49,737,578-49,777,248 forward strand.GRCm39:CM001004.3

This gene has 10 transcripts (splice variants), 221 orthologues, 19 paralogues and is associated with 20 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 32.4), cortex adult (RPKM 26.9) and 28 other tissues.

Summary

Enables protein serine/threonine/tyrosine kinase activity. Involved in peptidyl-serine phosphorylation; positive regulation of cellular protein metabolic process; and regulation of circadian rhythm. Acts upstream of or within several processes, including positive regulation of apoptotic signaling pathway; positive regulation of podosome assembly; and protein localization to tricellular tight junction. Located in cytosol and mitochondrion. Is expressed in several structures, including brain; extraembryonic component; future brain; genitourinary system; and spinal cord. Human ortholog(s) of this gene implicated in colorectal cancer; pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human MAPK9 (mitogen-activated protein kinase 9). [provided by Alliance of Genome Resources, Apr 2022]

Mapk9 Products (4)

mRNA Protein Name
NM_016961.3 NP_058657.1 mitogen-activated protein kinase 9 isoform beta1
NM_001163671.1 NP_001157143.1 mitogen-activated protein kinase 9 isoform beta2
NM_207692.2 NP_997575.2 mitogen-activated protein kinase 9 isoform alpha2
NM_001163672.1 NP_001157144.1 mitogen-activated protein kinase 9 isoform alpha1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables JUN kinase activity IDA
IDA: Inferred from direct assay
27830702 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10471813 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
24889144 MGI
enables protein serine/threonine/tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
29153991 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16458303 MGI
involved in inflammatory response to wounding IDA
IDA: Inferred from direct assay
27830702 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
15816869 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
15816869 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16458303 MGI
involved in positive regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
27830702 MGI
acts upstream of or within positive regulation of podosome assembly IMP
IMP: Inferred from mutant phenotype
24127566 MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
29153991 MGI
involved in positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
29153991 MGI
acts upstream of or within protein localization to tricellular tight junction IMP
IMP: Inferred from mutant phenotype
24889144 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
24889144 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22441692 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
22441692 MGI
acts upstream of or within response to cadmium ion IGI
IGI: Inferred from genetic interaction
16458303 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
15816869 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
15816869 MGI
is active in cytoplasm IDA
IDA: Inferred from direct assay
27830702 MGI
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
29153991 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11884367 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
11884367 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk9 Protein Structure

STKc_JNK

STKc_JNK: cd07850 (24 - 359)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 9

  • JNK/SAPK alpha

  • Jun kinase

  • MAP kinase 9

  • MAPK 9

  • c-Jun N-terminal kinase 2

  • protein kinase, mitogen-activated 9

  • stress-activated protein kinase JNK2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-RS08127 MAPK9 Human Pre-designed siRNA Set A / Unkown
HY-RS08128 Mapk9 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08129 Mapk9 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk9 NCBI NCBI:5601