HSPA6 - heat shock protein family A (Hsp70) member 6 Gene

Also Known as HSP70B'

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3310

About HSPA6

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,524,540-161,526,894 (from NCBI)

This gene has 1 transcript (splice variant), 52 orthologues and 13 paralogues.

Summary

Enables enzyme binding activity; heat shock protein binding activity; and unfolded protein binding activity. Involved in cellular response to heat and protein refolding. Located in centriole and cytosol. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

HSPA6 Products (1)

mRNA Protein Name
NM_002155.5 NP_002146.2 heat shock 70 kDa protein 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
21231916 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
23921388 GOA
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
21231916 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
enables unfolded protein binding IDA
IDA: Inferred from direct assay
21231916 GOA
Biological Process GO Annotation Evidence Verweise Source
NOT involved in cellular heat acclimation IMP
IMP: Inferred from mutant phenotype
21231916 GOA
involved in cellular response to heat IDA
IDA: Inferred from direct assay
24061851 GOA
involved in cellular response to heat IMP
IMP: Inferred from mutant phenotype
21597468 GOA
involved in protein refolding IDA
IDA: Inferred from direct assay
21231916 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
located in centriole IDA
IDA: Inferred from direct assay
24061851 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
24061851 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21231916 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA6 Protein Structure

HSP70

HSP70: Hsp70 protein (8 - 613)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 643 a.a.
Protein Preferred Names Protein Names

heat shock 70 kDa protein 6

  • epididymis secretory sperm binding protein

HSPA6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
HSPA6 P17066 C22orf15 Homo sapiens Q8WYQ4-2
Validated Y2H
32296183
Intra
HSPA6 P17066 COMMD6 Homo sapiens Q7Z4G1
Validated Y2H
32296183
Intra
HSPA6 P17066 PRAP1 Homo sapiens Q96NZ9
Validated Y2H
32296183
Intra
HSPA6 P17066 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
HSPA6 P17066 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
HSPA6 P17066 LGALS7 Homo sapiens P47929
Validated Y2H
32296183
Intra
HSPA6 P17066 PPIB Homo sapiens P23284
Validated Y2H
32296183
Intra
HSPA6 P17066 RPA1 Homo sapiens P27694
Validated Y2H
32296183
Intra
HSPA6 P17066 TERF1 Homo sapiens P54274
BiFC
21044950
Intra
HSPA6 P17066 TERF1 Homo sapiens P54274
Pull Down
21044950
Intra
HSPA6 P17066 KRT222 Homo sapiens Q8N1A0
Validated Y2H
32296183
Intra
HSPA6 P17066 FLNA Homo sapiens P21333-2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06435 HSPA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HSPA6 RGD RGD:1586661
Bos taurus HSPA6 VGNC VGNC:55236