ARRB2 - arrestin beta 2 Gene

Also Known as ARB2; ARR2; BARR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 409

About ARRB2

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,710,632-4,721,497 (from NCBI)

This gene has 20 transcripts (splice variants), 247 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 69.2), appendix (RPKM 43.9) and 21 other tissues.

Summary

Members of Arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as Hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like Arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for Arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

ARRB2 Products (7)

mRNA	Protein	Name
NM_001257328.2	NP_001244257.1	beta-arrestin-2 isoform 3
NM_001257329.2	NP_001244258.1	beta-arrestin-2 isoform 4
NM_001257330.2	NP_001244259.1	beta-arrestin-2 isoform 5
NM_001257331.2	NP_001244260.1	beta-arrestin-2 isoform 6
NM_001330064.2	NP_001316993.1	beta-arrestin-2 isoform 7
NM_004313.4	NP_004304.1	beta-arrestin-2 isoform 1
NM_199004.2	NP_945355.1	beta-arrestin-2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	33571431	GOA
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	10644702	GOA
enables angiotensin receptor binding	IPI IPI: Inferred from physical interaction	15611106	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	26839314	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12958365	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	18604210	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15878855	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in G protein-coupled receptor internalization	IDA IDA: Inferred from direct assay	10644702	GOA
involved in G protein-coupled receptor internalization	IMP IMP: Inferred from mutant phenotype	12582207	GOA
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	15635042	GOA
involved in desensitization of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12582207	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	15125834	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	26839314	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	18604210	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16378096	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	10644702	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	12582207	GOA
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	22457824	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	15878855	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	15878855	GOA
involved in receptor internalization	IDA IDA: Inferred from direct assay	12958365	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16820410	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	12958365	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12958365	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12958365	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	23341447	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16820410	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18604210	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARRB2 Protein Structure

Arrestin_N

Arrestin_C

0
100
200
300
409 a.a.

Protein Preferred Names	Protein Names
beta-arrestin-2	arrestin 3

ARRB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ARRB2	P32121	PPM1B	Homo sapiens	O75688	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	ZRANB2	Homo sapiens	O95218	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	S100A9	Homo sapiens	P06702	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	INSR	Homo sapiens	P06213-1	Anti Bait CoIP	19122674
Intra	ARRB2	P32121	PDE4D	Homo sapiens	Q08499	Anti Bait CoIP	19955404
Intra	ARRB2	P32121	PDE4D	Homo sapiens	Q08499	Anti Tag CoIP	17620599
Cross	ARRB2	P32121	Akt1	Mus musculus	P31750	Pull Down	16051150
Intra	ARRB2	P32121	NCL	Homo sapiens	P19338	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	GSN	Homo sapiens	P06396	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	PKM	Homo sapiens	P14618	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	CLTC	Homo sapiens	Q00610	FPS	37100772
Intra	ARRB2	P32121	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	PRP4K	Homo sapiens	Q13523	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	TCOF1	Homo sapiens	Q13428	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	TCOF1	Homo sapiens	Q13428	Anti Bait CoIP	17353931
Intra	ARRB2	P32121	NOLC1	Homo sapiens	Q14978	Anti Bait CoIP	17353931
Intra	ARRB2	P32121	NOLC1	Homo sapiens	Q14978	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	NOLC1	Homo sapiens	Q14978	Anti Tag CoIP	33961781
Intra	ARRB2	P32121	STK38	Homo sapiens	Q15208	Anti Tag CoIP	17620599
Intra	ARRB2	P32121	MAP3K5	Homo sapiens	Q99683	Peptide Array	19782076
Intra	ARRB2	P32121	ADRB2	Homo sapiens	P07550	Anti Tag CoIP	23208550
Intra	ARRB2	P32121	ADRB2	Homo sapiens	P07550	IF	23208550
Intra	ARRB2	P32121	SRC	Homo sapiens	P12931	Anti Bait CoIP	19202075
Cross	ARRB2	P32121	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034
Intra	ARRB2	P32121	EDNRA	Homo sapiens	P25101	Anti Bait CoIP	19202075
Intra	ARRB2	P32121	MAPK9	Homo sapiens	P45984	Y2H Array	31515488
Intra	ARRB2	P32121	MAPK9	Homo sapiens	P45984	Y2H Pooling	19060904
Intra	ARRB2	P32121	MAPK9	Homo sapiens	P45984	Y2H Array	19060904
Intra	ARRB2	P32121	MAPK9	Homo sapiens	P45984	Validated Y2H	32296183
Intra	ARRB2	P32121	MAPK9	Homo sapiens	P45984	Y2H Array	25416956
Intra	ARRB2	P32121	MAPK9	Homo sapiens	P45984	Y2H Prey Pooling	25416956
Intra	ARRB2	P32121	PDE4D	Homo sapiens	Q08499-2	Anti Tag CoIP	19955404
Intra	ARRB2	P32121	PPM1A	Homo sapiens	P35813	Anti Tag CoIP	17620599
Cross	ARRB2	P32121	rl	Drosophila melanogaster	P40417	Anti Tag CoIP	20802461

Cross: Cross-species interaction Intra: Intraspecies interaction

ARRB2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P85419	Beta Arrestin 2 Antibody (YA5111)	WB, IHC-P, ICC/IF, IP, ELISA, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Synovium Neoplasm	Synovial Neoplasm Tumor Of Synovium
Cecum Lymphoma	Cecal Lymphoma
Placenta Praevia	Placenta Previa Haemorrhage From Placenta Previa Placenta Previa Haemorrhage Lateral Placenta Low Implantation Of Placenta Nos Or With Haemorrhage Total Placenta Previa Total Placenta Praevia Nos Or With Haemorrhage Placental Previa Haemorrhage Pp - [Placenta Previa] Placenta Previa Marginalis Placenta Previa Partialis Partial Placenta Previa Placenta Previa Centralis Low Implantation Of Placenta Low Implantation Or Insertion Of Placenta Low Insertion Of Placenta Low Lying Placenta Marginal Placenta Marginal Placenta Praevia Nos Or With Haemorrhage Marginal Placenta Previa Marginal Placental Haemorrhage Partial Placenta Praevia Nos Or With Haemorrhage
Retinal Degeneration	Degeneration Of Retina
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson
Whim Syndrome 1	Whim Syndrome Whims Warts, Hypogammaglobulinemia, Infections, And Myelokathexis WHIMS1 Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1 Myelokathexis, Isolated Wilm Warts-Infections-Leukopenia-Myelokatexis Syndrome Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Opioid Abuse	Opioid-Related Disorders
Pain Agnosia	Analgesia
Nephrogenic Syndrome Of Inappropriate Antidiuresis	NSIAD
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Morphine Dependence
Marfan Syndrome	MFS Mfs1 Marfan'S Syndrome Marfan Syndrome Type 1 Marfan Syndrome, Type I Mass Phenotype Contractural Arachnodactyly Mass Syndrome Octd Overlap Connective Tissue Disease Marfanoid Hypermobility Syndrome Marfan Disease
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Constipation
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01029	ARRB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20857	Arrb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27372	Arrb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARRB2	VGNC	VGNC:70022
Canis familiaris	ARRB2	VGNC	VGNC:38137
Bos taurus	ARRB2	VGNC	VGNC:26170
Felis catus	ARRB2	VGNC	VGNC:97355
Mus musculus	ARRB2	MGD	MGI:99474
Rattus norvegicus	ARRB2	RGD	RGD:2157
Others	ARRB2	NCBI