PIN4 - peptidylprolyl cis/trans isomerase, NIMA-interacting 4 Gene

Also Known as EPVH; PAR14; PAR17

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5303

About PIN4

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:72,181,676-72,263,964 (from NCBI)

This gene has 9 transcripts (splice variants), 231 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 5.5), kidney (RPKM 4.8) and 25 other tissues.

Summary

This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]

PIN4 Products (2)

mRNA Protein Name
NM_001170747.1 NP_001164218.1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2
NM_006223.4 NP_006214.3 peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables bent DNA binding IDA
IDA: Inferred from direct assay
12144781 GOA
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
17875217 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in rRNA processing IMP
IMP: Inferred from mutant phenotype
19369196 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12144781 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
17875217 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
19369196 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12144781 GOA
part of preribosome IDA
IDA: Inferred from direct assay
19369196 GOA
located in spindle IDA
IDA: Inferred from direct assay
19369196 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIN4 Protein Structure

Rotamase_3

Rotamase_3: PPIC-type PPIASE domain (59 - 156)

  • 0
  • 100
  • 156 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

  • PPIase PIN4

PIN4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PIN4 Q9Y237 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
PIN4 Q9Y237 FAM9B Homo sapiens Q8IZU0
Y2H Array
31515488
Intra
PIN4 Q9Y237 MAGEA11 Homo sapiens P43364-2
Y2H Prey Pooling
25416956
Intra
PIN4 Q9Y237 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
25416956
Intra
PIN4 Q9Y237 PNMA1 Homo sapiens Q8ND90
Validated Y2H
25416956
Intra
PIN4 Q9Y237 PNMA1 Homo sapiens Q8ND90
Y2H Array
25416956
Intra
PIN4 Q9Y237 ZBTB9 Homo sapiens Q96C00
Validated Y2H
25416956
Intra
PIN4 Q9Y237 ZBTB9 Homo sapiens Q96C00
Y2H Array
25416956
Intra
PIN4 Q9Y237 ZBTB9 Homo sapiens Q96C00
Y2H Array
31515488
Intra
PIN4 Q9Y237 ZBTB9 Homo sapiens Q96C00
Y2H Prey Pooling
25416956
Intra
PIN4 Q9Y237 CEP72 Homo sapiens Q9P209
Y2H Prey Pooling
25416956
Intra
PIN4 Q9Y237 CEP72 Homo sapiens Q9P209
Y2H Array
31515488
Intra
PIN4 Q9Y237 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PIN4 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71205 PIN4 Protein, Human (His) Q9Y237-2 (M1-K156) ≥ 95%, as determined by reducing SDS-PAGE.

PIN4 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81896 PIN4 Antibody (YA1641) WB, IP Human, Rat, Hamster
HY-P81896A PIN4 Antibody (YA1641)(PBS only) WB, IP Human, Rat, Hamster

Related Diseases

Diseases Alias
Prostatic Acinar Adenocarcinoma

  • Acinar Prostate Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10558 PIN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21410 Pin4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27929 Pin4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PIN4 VGNC VGNC:103741
Bos taurus PIN4 VGNC VGNC:32903
Rattus norvegicus PIN4 RGD RGD:1590326
Mus musculus PIN4 MGD MGI:1916963
Others PIN4 NCBI