RAD23B - RAD23 homolog B, nucleotide excision repair protein Gene

Also Known as P58; HR23B; HHR23B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5887

About RAD23B

Cytogenetic location: 9q31.2 Genomic coordinates (GRCh38): 9:107,283,279-107,332,194 (from NCBI)

This gene has 5 transcripts (splice variants), 232 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 44.7), fat (RPKM 43.3) and 25 other tissues.

Summary

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S Proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

RAD23B Products (3)

mRNA Protein Name
NM_001244713.1 NP_001231642.1 UV excision repair protein RAD23 homolog B isoform 2
NM_001244724.2 NP_001231653.1 UV excision repair protein RAD23 homolog B isoform 3
NM_002874.5 NP_002865.1 UV excision repair protein RAD23 homolog B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA damage sensor activity IDA
IDA: Inferred from direct assay
19941824 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
19435460 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10488153 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in nucleotide-excision repair IDA
IDA: Inferred from direct assay
8168482 GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19435460 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of XPC complex IDA
IDA: Inferred from direct assay
11279143 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD23B Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (6 - 77)

UBA

UBA: UBA/TS-N domain (190 - 225)

XPC-binding

XPC-binding: XPC-binding domain (276 - 333)

UBA

UBA: UBA/TS-N domain (367 - 401)

  • 0
  • 100
  • 200
  • 300
  • 409 a.a.
Protein Preferred Names Protein Names

UV excision repair protein RAD23 homolog B

  • RAD23, yeast homolog of, B

RAD23B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RAD23B P54727 PNMA5 Homo sapiens Q96PV4
Validated Y2H
32296183
Intra
RAD23B P54727 PNMA5 Homo sapiens Q96PV4
Y2H Array
25416956
Intra
RAD23B P54727 PNMA5 Homo sapiens Q96PV4
Y2H Array
32296183
Intra
RAD23B P54727 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
25416956
Intra
RAD23B P54727 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 PUF60 Homo sapiens Q9UHX1
Y2H Prey Pooling
25416956
Intra
RAD23B P54727 PUF60 Homo sapiens Q9UHX1
Y2H Array
25416956
Intra
RAD23B P54727 PUF60 Homo sapiens Q9UHX1-2
Y2H Array
32296183
Intra
RAD23B P54727 PUF60 Homo sapiens Q9UHX1-2
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 PUF60 Homo sapiens Q9UHX1-2
Validated Y2H
32296183
Intra
RAD23B P54727 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
RAD23B P54727 POU6F2 Homo sapiens P78424
Validated Y2H
32296183
Intra
RAD23B P54727 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Cross
RAD23B P54727 Pax3 Mus musculus P24610
Pull Down
17662948
Intra
RAD23B P54727 USP25 Homo sapiens Q9UHP3
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 USP25 Homo sapiens Q9UHP3
Anti Tag CoIP
33961781
Intra
RAD23B P54727 USP25 Homo sapiens Q9UHP3
Anti Tag CoIP
28514442
Intra
RAD23B P54727 USP25 Homo sapiens Q9UHP3
Validated Y2H
32296183
Intra
RAD23B P54727 USP25 Homo sapiens Q9UHP3
Y2H Array
32296183
Intra
RAD23B P54727 UBC Homo sapiens P0CG48
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 UBC Homo sapiens P0CG48
Y2H Array
32296183
Intra
RAD23B P54727 VIM Homo sapiens P08670
Pull Down
16712842
Intra
RAD23B P54727 PSMD4 Homo sapiens P55036
Density Sedimentation
10488153
Intra
RAD23B P54727 PSMD4 Homo sapiens P55036
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 PSMD4 Homo sapiens P55036
Validated Y2H
32296183
Intra
RAD23B P54727 PSMD4 Homo sapiens P55036
Y2H Array
32296183
Intra
RAD23B P54727 PSMD4 Homo sapiens P55036
Pull Down
20059542
Intra
RAD23B P54727 PSMD4 Homo sapiens P55036
Pull Down
10488153
Intra
RAD23B P54727 PSMC2 Homo sapiens P35998
Pull Down
16712842
Intra
RAD23B P54727 XPC Homo sapiens Q01831
Anti Tag CoIP
33961781
Intra
RAD23B P54727 XPC Homo sapiens Q01831
Anti Tag CoIP
28514442
Intra
RAD23B P54727 XPC Homo sapiens Q01831
Affinity Chrom
21962512
Intra
RAD23B P54727 MKRN1 Homo sapiens Q9UHC7
Y2H Array
32296183
Intra
RAD23B P54727 MKRN1 Homo sapiens Q9UHC7
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 MKRN1 Homo sapiens Q9UHC7
Validated Y2H
32296183
Intra
RAD23B P54727 RSC1A1 Homo sapiens Q92681
Validated Y2H
32296183
Intra
RAD23B P54727 RSC1A1 Homo sapiens Q92681
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 RSC1A1 Homo sapiens Q92681
Y2H Array
32296183
Intra
RAD23B P54727 UBB Homo sapiens P0CG47
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 UBB Homo sapiens P0CG47
Pull Down
17662948
Intra
RAD23B P54727 UBB Homo sapiens P0CG47
Y2H Array
32296183
Intra
RAD23B P54727 HIP1 Homo sapiens O00291
Y2H Array
32296183
Intra
RAD23B P54727 HIP1 Homo sapiens O00291
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra
RAD23B P54727 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
32296183
Intra
RAD23B P54727 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Y2H Prey Pooling
25416956
Intra
RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Anti Tag CoIP
33961781
Intra
RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Validated Y2H
25416956
Intra
RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Anti Tag CoIP
28514442
Intra
RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Validated Y2H
32296183
Intra
RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Y2H Array
25416956
Intra
RAD23B P54727 UBA3 Homo sapiens Q8TBC4
Pull Down
16712842
Intra
RAD23B P54727 USP5 Homo sapiens P45974
Pull Down
16712842
Intra
RAD23B P54727 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
RAD23B P54727 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
RAD23B P54727 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
RAD23B P54727 ADRM1 Homo sapiens Q16186
Pull Down
20059542
Cross: Cross-species interaction Intra: Intraspecies interaction

RAD23B Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81330 Rad23B Antibody (YA1075) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat, Monkey, Hamster
HY-P81330A Rad23B Antibody (YA1075)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat, Monkey, Hamster
HY-P84397 Rad23B Antibody (YA4094) WB, IHC-P, ICC/IF, FC Human, Mouse
HY-P84397A Rad23B Antibody (YA4094)(PBS only) WB, IHC-P, ICC/IF, FC Human, Mouse
HY-P85594 Rad23B Antibody (YA5286) WB, ICC/IF, IHC-P Human, Mouse, Rat, Monkey, Hamster

Related Diseases

Diseases Alias
Xeroderma Pigmentosum, Variant Type

  • Xeroderma Pigmentosum

  • XPV

  • Xeroderma Pigmentosum Variant Type

  • Xeroderma Pigmentosum With Normal Dna Repair Rates

  • Photosensitivity With Defective Dna Synthesis

  • Xp

  • De Sanctis-Cacchione Syndrome

  • Desanctis-Cacchione Syndrome

  • Xeroderma Pigmentosa

  • Xerodermic Idiocy

  • Xeroderma Pigmentosum Variant

  • Xp - [Xeroderma Pigmentosum]

  • Atrophoderma Pigmentosum
Xeroderma Pigmentosum, Complementation Group C

  • Xeroderma Pigmentosum, Group C

  • XPC

  • Xpcc

  • Xeroderma Pigmentosum Iii

  • Xp3

  • Xeroderma Pigmentosum Group C

  • Xp Group C

  • Xp, Group C

  • Xeroderma Pigmentosum, Type 3

  • Xeroderma Pigmentosum Complementation Group C

  • XP-C
Xeroderma Pigmentosum, Complementation Group G

  • Xeroderma Pigmentosum, Group G

  • Xeroderma Pigmentosum Vii

  • Xp7

  • XPG

  • Xeroderma Pigmentosum Group G

  • Xp Group G

  • Xp, Group G

  • Xpgc

  • Xeroderma Pigmentosum, Group G/Cockayne Syndrome

  • Xeroderma Pigmentosum, Type 7

  • Xeroderma Pigmentosum Complementation Group G

  • XP-G

  • Xp-G/Cs

  • Xeroderma Pigmentosum Group G/Cockayne Syndrome
Xeroderma Pigmentosum, Complementation Group A

  • Xeroderma Pigmentosum Group A

  • Xp1

  • Xeroderma Pigmentosum, Group A

  • XPA

  • Xeroderma Pigmentosum I

  • Xeroderma Pigmentosum Complementation Group A

  • Xp Group A

  • Xp, Group A

  • Xeroderma Pigmentosum 1

  • Xeroderma Pigmentosum, Type 1

  • XP-A
Xeroderma Pigmentosum, Complementation Group F

  • Xeroderma Pigmentosum, Group F

  • Xeroderma Pigmentosum Vi

  • Xp6

  • Xeroderma Pigmentosum, Type F/Cockayne Syndrome

  • XPF

  • Xp, Group F

  • Xeroderma Pigmentosum Group F

  • Xp Group F

  • Xeroderma Pigmentosum, Type 6

  • Xeroderma Pigmentosum Complementation Group F

  • XP-F

  • Xeroderma Pigmentosum Type F/Cockayne Syndrome

  • XPF/CS
Cockayne Syndrome A

  • Cockayne Syndrome Type 1

  • Cockayne Syndrome, Type A

  • Cockayne Syndrome Type I

  • CSA

  • Cockayne Syndrome Classic Form

  • Cockayne Syndrome Classical

  • Cockayne Syndrome Type A

  • Ckn1
Cockayne Syndrome B

  • Cockayne Syndrome Type 2

  • Cockayne Syndrome, Type B

  • Cockayne Syndrome Type Ii

  • CSB

  • Cockayne Syndrome 2

  • Cockayne Syndrome Type B

  • Ckn2

  • Cockayne Syndrome, Type Ii
De Sanctis-Cacchione Syndrome

  • Xerodermic Idiocy

  • Xeroderma Pigmentosum With Neurologic Manifestation

  • DSC

  • Xerodermic Idiocy Of De Sanctis And Cacchione
Uv-Sensitive Syndrome

  • Uvss

  • Uv Sensitive Syndrome

  • Ultraviolet Sensitive Syndrome
Trichothiodystrophy

  • Ttd

  • Amish Brittle Hair Syndrome

  • Bids Syndrome

  • Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

  • Ibids

  • Pibids

  • Trichothiodystrophy Syndromes
Cerebrooculofacioskeletal Syndrome

  • Cerebro-Oculo-Facio-Skeletal Syndrome

  • Cofs Syndrome

  • Pena-Shokeir Syndrome Type 2

  • Pena Shokeir Syndrome Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11601 RAD23B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAD23B MGD MGI:105128
Bos taurus RAD23B VGNC VGNC:33683
Macaca mulatta RAD23B VGNC VGNC:76644
Rattus norvegicus RAD23B RGD RGD:1562958
Canis familiaris RAD23B VGNC VGNC:45316
Felis catus RAD23B VGNC VGNC:69214
Others RAD23B NCBI