TYRO3 - TYRO3 protein tyrosine kinase Gene

Also Known as BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7301

About TYRO3

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,559,212-41,583,589 (from NCBI)

This gene has 9 transcripts (splice variants), 206 orthologues and 53 paralogues. Broad expression in ovary (RPKM 23.1), brain (RPKM 22.4) and 14 other tissues.

Summary

The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

TYRO3 Products (2)

mRNA	Protein	Name
NM_001330264.2	NP_001317193.1	tyrosine-protein kinase receptor TYRO3 isoform 2
NM_006293.4	NP_006284.2	tyrosine-protein kinase receptor TYRO3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	10627473	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7634325	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7537495	GOA
enables virus receptor activity	IDA IDA: Inferred from direct assay	22156524	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in positive regulation of viral life cycle	IMP IMP: Inferred from mutant phenotype	22673088	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	7511603	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cell surface	IDA IDA: Inferred from direct assay	7511603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TYRO3 Protein Structure

I-set

Ig_2

fn3

Pkinase_Tyr

0
200
400
600
800
890 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase receptor TYRO3	tyrosine-protein kinase DTK

TYRO3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TYRO3	Q06418	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	TYRO3	Q06418	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	TYRO3	Q06418	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	TYRO3	Q06418	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	TYRO3	Q06418	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	TYRO3	Q06418	KLK4	Homo sapiens	Q9Y5K2	Y2H Prey Pooling	25416956
Intra	TYRO3	Q06418	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	TYRO3	Q06418	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	TYRO3	Q06418	HSP90AB1	Homo sapiens	P08238	Affinity Chrom	35384245
Intra	TYRO3	Q06418	KRTAP5-9	Homo sapiens	P26371	Y2H	21516116
Intra	TYRO3	Q06418	KRTAP5-9	Homo sapiens	P26371	Y2H Array	31515488
Intra	TYRO3	Q06418	GRB2	Homo sapiens	P62993	Affinity Chrom	35384245

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TYRO3 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70057	TYRO3/DTK Protein, Human (388a.a, HEK293, His)	Q06418 (A41-S428)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78657	TYRO3/DTK Protein, Human (Q261H, HEK293, Fc)	Q06418/AAH51756.1 (A41-S428, Q261H)	≥ 95%, as determined by reducing SDS-PAGE.

TYRO3 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P84496	TYRO3 Antibody (YA4193)	ELISA	Human
HY-P84496A	TYRO3 Antibody (YA4193)(PBS only)	ELISA	Human
HY-P84497	TYRO3 Antibody (YA4194)	IHC-P, FC, ELISA	Human
HY-P84497A	TYRO3 Antibody (YA4194)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85403	TYRO3 Antibody (YA5095)	IHC-P, IHC-F, ICC/IF, IP, IF-Tissue	Human, Mouse, Rat
HY-P87503	TYRO3 Antibody (YA7188)	WB	Human, Rat

Related Diseases

Diseases	Alias
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Zika Fever	Zika Virus Infection Zika Virus Disease Zika Virus Zika Virus Fever Mosquito-Borne Viral Fever, Zika
La Crosse Encephalitis	California Encephalitis California Virus Encephalitis Neuroinvasive California Encephalitis Virus Infection Californian Encephalitis Encephalitis, California California Meningoencephalitis California Encephalitis Virus Infection California Encephalitis Virus Infection Neuroinvasive Disease California Meningoencephalitis Virus Disease California Serogroup Virus Neuroinvasive Disease California Viral Encephalitis Ce - [California Encephalitis] Lac - [La Crosse Encephalitis]
Retinal Degeneration	Degeneration Of Retina
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-12076	BMS 777607	Inhibitor	99.36%	Phase 2
HY-114358	Tamnorzatinib	Inhibitor	98.59%	Phase 2
HY-147218	PF-07265807	Inhibitor	95.18%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-12494	LDC1267	Inhibitor	99.64%	Unkown
HY-117596	UNC569	Inhibitor	99.92%	Unkown
HY-132200	UNC5293	Inhibitor	99.93%	Unkown
HY-173268	UNC9426	Inhibitor	99.51%	Unkown
HY-117548	UNC1062	Inhibitor	98.92%	Unkown
HY-124502	UNC4203	Inhibitor	99.80%	Unkown
HY-162085	Axl-IN-17	Inhibitor	/	Unkown
HY-173400	UNC8212	Inhibitor	/	Unkown
HY-115778	UNC3133	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TYRO3	RGD	RGD:3923
Macaca mulatta	TYRO3	VGNC	VGNC:78683
Bos taurus	TYRO3	VGNC	VGNC:36551
Felis catus	TYRO3	VGNC	VGNC:66739
Mus musculus	TYRO3	MGD	MGI:104294
Canis familiaris	TYRO3	VGNC	VGNC:48027
Others	TYRO3	NCBI