HBT1
Based on 1 Customer Validation
HBT1 is an effective AMPA receptor AMPA-R potentiator. HBT1 specifically binds to the ligand-binding domain (LBD) of AMPAR and enhances receptor activity only when AMPA is present., HBT1 has almost no agonistic effect (i.e., reaching the optimal concentration, and then the efficacy decreases as the concentration continues to increase) compared with traditional AMPA-R potentiator, avoiding the bell-shaped reaction of brain-derived neurotrophic factor (BDNF) production in primary neurons. HBT1 can be applicable to a wider range of neurological and psychiatric diseases (such as depression, Alzheimer's disease, etc.).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.73%
- CAS. Nr.: 489408-02-8
- Formel: C16H17F3N4O2S
- Molecular Weight:386.39
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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AMPA Receptor |
HBT1 (0.01-100 μM) activates AMPA receptors through glutamate dependence (EC₅₀ = 2.5 μM), inducing calcium ion influx in primary neurons and CHO cells with EC₅₀ values of 1.3 and 4.6 μM, respectively[1].
HBT1 (0-10 μM) concentration-dependently increases BDNF protein levels in the presence of AMPA and shows no increase of BDNF protein levels in the absence of AMPA in primary neurons and CHO cells[1].
[3H]-HBT1 (1 nM-100 μM) binds native AMPA-R with a Kd of 416 nM and inhibits rat hippocampal membranes with an IC₅₀ of 0.28 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 489408-02-8
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Appearance Solid
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Molecular Weight 386.39
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Formel C16H17F3N4O2S
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Color White to off-white
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SMILES
O=C(NC1=C(C(N)=O)C(CCCC2)=C2S1)CN3N=C(C(F)(F)F)C=C3C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HBT1 Related Classifications
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