Human UGT1A6
Human UGT1A6 is a UDP-glucuronosyltransferase. UGT1A6 catalyzes the glucuronidation of 5-hydroxytryptamine (HY-B1473A), 1-Naphthol (HY-Y1309), and Acetaminophen (HY-66005). Human UGT1A6 can be used in studies related to the pathogenesis of bladder cancer.
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
UGT1A6 |
In Vitro
UGT1A6 efficiently catalyzes the glucuronidation of 5-hydroxytryptamine (HY-B1473A) (Km = 165 µM) and 1-Naphthol (HY-Y1309) (Km = 43 µM), with no detectable activity toward morphine[1].
Human UGT1A6 is expressed in cells and mediates the glucuronidation of Acetaminophen (HY-66005), with a Km value of 2 mM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[Human UGT1A6]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. King CD, et al. Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate. Arch Biochem Biophys. 1999 May 1;365(1):156-62. [Content Brief]
[2]. Bock KW, et al. UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. Methods Enzymol. 2005;400:57-75. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Human UGT1A6 Related Classifications
HY-E72108 Related Classifications
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