Isatin-O
Isatin-O (Isatin β-oxime; Isatin 3-oxime) is an acetylcholinesterase (AChE) reactivator capable of crossing the blood-brain barrier. Isatin-O reactivates paraoxon-inhibited acetylcholinesterase in the central and peripheral nervous systems. As a glycosylation substrate, Isatin-O undergoes complete glycosylation in a Rauvolfia serpentina cell suspension culture system to form isatin-3-oxime-glucoside. Isatin-O can be used in studies related to organophosphate poisoning.
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- CAS. Nr.: 607-28-3
- Formel: C8H6N2O2
- Molecular Weight:162.15
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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AChE |
Isatin-O (10-100 μmol/L; 10-120 min) reactivates paraoxon-inhibited Electrophorus electricus acetylcholinesterase, reaching ~8% reactivation at 10 μmol/L within 10 min and ~23% reactivation at 100 μmol/L after 120 min, with better initial reactivation performance than 2-PAM at 10 μmol/L[1].
Isatin-O (5.76 mM; 72 h) is completely glucosylated by Rauvolfia serpentina plant cell suspension cultures to form Isatin-3-oxime-β-D-glucopyranoside within 72 h, with the glucoside accumulating intracellularly without further metabolism[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 607-28-3
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Molecular Weight 162.15
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Formel C8H6N2O2
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SMILES
O=C1NC=2C=CC=CC2C1=NO
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Synonyms
Isatin β-oxime; Isatin 3-oxime
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. de Paula RL, et al. Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon. Molecules (Basel, Switzerland). 2018 Nov 12;23(11):2954. [Content Brief]
[2]. Hinse C, et al. Glucosylation of isatin-3-oxime followed by 2D in situ NMR in plant cells at highest magnetic field without labelling. Natural product letters. 2001;15(2):119-24. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Isatin-O Related Classifications
HY-115841 Related Classifications
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- Isatin-O
- 607-28-3
- Isatin β-oxime
- Isatin 3-oxime
- Cholinesterase (ChE)
- peripheral nervous systems
- acetylcholinesterase
- isatin-3-oxime-glucoside
- blood-brain barrier
- glucosylation substrate
- Electrophorus electricus acetylcholinesterase
- paraoxon-inhibited acetylcholinesterase
- Rauvolfia serpentina cell suspension cultures
- organophosphate poisoning
- central nervous systems
- Inhibitor
- inhibitor
- inhibit