Isoconazole
Based on 2 publication(s) in Google Scholar
Isoconazole is an antifungal agent against Candida albicans. Isoconazole is a broad-spectrum antimicrobial azole that can be studied in research on dermatomycoses.
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- CAS. Nr.: 27523-40-6
- Formel: C18H14Cl4N2O
- Molecular Weight:416.13
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Isoconazole
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Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 27523-40-6
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Molecular Weight 416.13
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Formel C18H14Cl4N2O
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SMILES
ClC1=CC=C(C(CN2C=NC=C2)OCC3=C(Cl)C=CC=C3Cl)C(Cl)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Chem Biol Interact
Metallothioneins protect against isoconazole nitrate-induced antitumor activity through the maintenance of cellular redox homeostasis in hepatocellular carcinoma. [Abstract]2025 Sep 5:418:111614. PMID: 40541645 -
Int J Parasitol Drugs Drug Resist
Lower micromolar activity of the antifungal imidazoles on the bacterial-type bifunctional aldehyde/alcohol dehydrogenase (AdhE) in Cryptosporidium parvum and in vitro efficacy against the zoonotic parasite. [Abstract]2024 Aug:25:100551. PMID: 38875756
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
Verweise
[1]. Frenzel, U. H., & Gutekunst, A. (1983). Contact dermatitis to isoconazole nitrate. Contact dermatitis, 9(1), 74. [Content Brief]
[2]. Veraldi S. (2013). Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids. Mycoses, 56 Suppl 1, 3–15. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Isoconazole Related Classifications
HY-W895978 Related Classifications
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