1. Anti-infection
  2. Bacterial
    Fungal
    Antibiotic
  3. Isoconazole nitrate

Isoconazole nitrate 

Cat. No.: HY-B1444 Purity: ≥98.0%
Handling Instructions

Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential.

For research use only. We do not sell to patients.

Isoconazole nitrate Chemical Structure

Isoconazole nitrate Chemical Structure

CAS No. : 24168-96-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 94 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential[1].

In Vitro

Isoconazole nitrate also exerts several other effects on the fungal membrane, which are independent of inhibition of the ergosterol synthesis. Isoconazole nitrate (ISN) causes a rapid reduction of cellular adenosine triphosphate (ATP) within 10 min of in vitro exposure[1].
Isoconazole nitrate (1, 10 μg/mL) induces a blockade of cell division in vitro by its action on synthesis and organisation of the cell membrane. Isoconazole nitrate (50, 100 μg/mL), ISN induced necrosis and death of fungal cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

479.14

Formula

C₁₈H₁₅Cl₄N₃O₄

CAS No.
SMILES

ClC1=C(COC(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)C(Cl)=CC=C1.O[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (208.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0871 mL 10.4354 mL 20.8707 mL
5 mM 0.4174 mL 2.0871 mL 4.1741 mL
10 mM 0.2087 mL 1.0435 mL 2.0871 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Keywords:

IsoconazoleBacterialFungalAntibioticInhibitorinhibitorinhibit

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Product Name:
Isoconazole nitrate
Cat. No.:
HY-B1444
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