K783-0308
K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase.
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- CAS. Nr.: 422554-29-8
- Formel: C21H23N3O
- Molecular Weight:333.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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MNK2 406 nM (IC50) |
K783-0308 (MOLM-13, MV-4-11 cells) shows cytotoxic effect against MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells[1].
K783-0308 (1, 3, 10, 30 µM) promotes AML cell apoptosis and cell cycle arrests in the G0/G1 phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLM-13, MV-4-11 cells (RPMI-1640 supplemented with streptomycin (100 µg/mL)/penicillin (100 U/mL)/ amphotericin B (0.25 µg/mL))
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Concentration:1, 3, 10, 30 µM
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Incubation Time:48 h, 72 h
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Result:Promotes AML cell apoptosis and cell cycle arrested in the G0/G1 phase.
Chemical Information
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CAS. Nr. 422554-29-8
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Molecular Weight 333.43
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Formel C21H23N3O
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SMILES
O=C(C1=CC=C2C(N=CN2C3=CC=C(CC)C=C3)=C1)NC4CCCC4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
K783-0308 Related Classifications
HY-115906 Related Classifications
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