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Lorigerlimab

(Synonyms: MGD019)
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Lorigerlimab (MGD019) is a bispecific IgG4 dual-affinity re-targeting antibody (DART). Lorigerlimab can block PD-1 and CTLA-4, and improves T-cell responses. Lorigerlimab can be used for research of metastatic castration-resistant prostate cancer (mCRPC).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 97.5%
  • CAS. Nr.: 2416595-46-3
  • Molecular Weight:166.4 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Lorigerlimab
  • Experimental Validation Results for Lorigerlimab
  • Experimental Validation Results for Lorigerlimab
  • Experimental Validation Results for Lorigerlimab
  • Lorigerlimab Chemical Structure
    Lorigerlimab Chemical Structure
CAS. Nr.: 2416595-46-3
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Lorigerlimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    [V-kappa'-VH-h-CH2-CH3_V-kappa-VH']2

  • 1/16

    Immobilized PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) can bind Lorigerlimab. The EC50 for this effect is 36.2 ng/mL.

  • 1/16

    Immobilized CTLA-4 Protein, Human (HEK293, HY-P72959) can bind Lorigerlimab. The EC50 for this effect is 38.3 ng/mL.

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CTLA4 (red) with Lorigerlimab (HY-P99714). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Lorigerlimab Chemical Structure
    1/16
  • Lorigerlimab
  • Immobilized PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) can bind Lorigerlimab. The EC50 for this effect is 36.2 ng/mL.
  • Immobilized CTLA-4 Protein, Human (HEK293, HY-P72959) can bind Lorigerlimab. The EC50 for this effect is 38.3 ng/mL.
  • Flow Cytometry analysis of Raji cells labelling CTLA4 (red) with Lorigerlimab (HY-P99714). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • [V-kappa'-VH-h-CH2-CH3_V-kappa-VH']2