Luotonin F
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II.
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- CAS. Nr.: 244616-85-1
- Formel: C18H11N3O2
- Molecular Weight:301.30
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
[2]|
Topoisomerase II |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| P388 | IC50 |
20 μg/mL
Compound: 4
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Cytotoxic activity against mouse leukemia P-388 cells
Cytotoxic activity against mouse leukemia P-388 cells
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[PMID: 14980663] |
In Vitro
Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells (IC50: 2.3 μg/mL)[1].
Luotonin F (25 μM) inhibits human topoisomerase II[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 244616-85-1
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Molecular Weight 301.30
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Formel C18H11N3O2
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SMILES
O=C1NC(C(C2=CC3=C(N=C2)C=CC=C3)=O)=NC4=CC=CC=C41
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Liang JL, et al. Recent advances in the studies on luotonins. Molecules. 2011 Jun 14;16(6):4861-83. [Content Brief]
[2]. Ma Z, et al. Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1193-6. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Luotonin F Related Classifications
HY-118726 Related Classifications
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