Methyl pyropheophorbide-a
Based on 2 publication(s) in Google Scholar
Methyl pyropheophorbide-a (Pyropheophorbide-a methyl ester), a chlorophyll-a derivative, is a potent photosensitizer that can be used in photodynamic therapy (PDT) of cancer. Methyl pyropheophorbide-a has photodynamic activity and can induce apoptosis and inhibit tumor growth.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.14%
- CAS. Nr.: 6453-67-4
- Formel: C34H36N4O3
- Molecular Weight:548.67
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Methyl pyropheophorbide-a
More
Biologische Aktivität
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.28 μM
Compound: 1, MPPa
|
Cytotoxicity against human HeLa cells of light exposed compound after 12 hrs by WST-8 assay
Cytotoxicity against human HeLa cells of light exposed compound after 12 hrs by WST-8 assay
|
[PMID: 22335896] |
Pyropheophorbide-a methyl ester (2 μM; 12 h) inhibits the cell cycle progression from the G0/G1-phases and induces apoptosis at the light dosage of 55.6 kJ/m2 in PC-3M cells[2].
Pyropheophorbide-a methyl ester (0.2-15 μM; 20 h) has no signi?cant dark cytotoxicity in NCI-h446 cells[1].
Pyropheophorbide-a methyl ester (0.1-15 μM; 20 h) mediates a dose-dependent photocytotoxicity in the NCI-h446 cells[1].
Pyropheophorbide-a methyl ester (2-4 μM; 0-24 h) induces apoptosis of NCI-h446 cells in a time-dependent manner[1].
Pyropheophorbide-a methyl ester (0.5-4 μM; 0-20 h) shows a photocytotoxicity in PC-3M cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:PC-3M cells
-
Concentration:2 μM
-
Incubation Time:12 h
-
Result:Apoptosis rate was about 0.27%, 6.15%, 20.49%, 50.76%, 65.39%, 64.92%, and 64.37% at 1, 3, 6, 12, 18, and 24 h posttreatment, respectively under the conditions of LC75 (2 μM+55.6 kJ/m2).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male BALB/c nude mice (6-8 weeks, 16-20 g) bearing PC-3M tumor[2]
-
Dosage:15 mg/kg
-
Administration:Tail vein injection and topical injection
-
Result:The tumor volume and the weight inhibition rate were 46.78%, 41.84% in tail vein injection group and 78.66%, 72.07% in topical injection group, respectively.
Chemical Information
-
CAS. Nr. 6453-67-4
-
Appearance Solid
-
Molecular Weight 548.67
-
Formel C34H36N4O3
-
Color Blue to dark blue
-
SMILES
CC1=C(N2)/C=C(C(CC)=C3C)\N=C3/C=C(C(C=C)=C/4C)\NC4=C/C5=N/C([C@H]([C@@H]5C)CCC(OC)=O)=C(C6)\C2=C1C6=O
-
Synonyms
Pyropheophorbide-a methyl ester
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Cell Prolif
2025 Jul 16:e70097. PMID: 40670295 -
Lösungsmittel & Löslichkeit
DMSO : 2.5 mg/mL (4.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (281 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Sun X, et, al. Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis. Photochem Photobiol. 2002 Jun;75(6):644-51. [Content Brief]
[2]. Tian Y, et, al. Cell death induced by MPPa-PDT in prostate carcinoma in vitro and in vivo. Biochem Biophys Res Commun. 2006 Sep 22;348(2):413-20. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8226 mL | 9.1129 mL | 18.2259 mL | 45.5647 mL |
Methyl pyropheophorbide-a Related Classifications
HY-137473 Related Classifications
Powered by Bioz