Monolaurin
Based on 2 publication(s) in Google Scholar
Monolaurin (1-Monolaurin) is an orally active antibiotic with antiviral and antibacterial properties.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.97%
- CAS. Nr.: 142-18-7
- Formel: C15H30O4
- Molecular Weight:274.40
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Monolaurin
More
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A498 | ED50 |
3.77 μg/mL
Compound: 1
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Cytotoxicity against human A498 cells after 7 days by MTT assay
Cytotoxicity against human A498 cells after 7 days by MTT assay
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[PMID: 9134750] |
| MIA PaCa-2 | ED50 |
2.33 μg/mL
Compound: 1
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Cytotoxicity against human MIAPaCa2 cells after 7 days by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 7 days by MTT assay
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[PMID: 9134750] |
| PC-3 | ED50 |
23.28 μg/mL
Compound: 1
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Cytotoxicity against human PC3 cells after 7 days by MTT assay
Cytotoxicity against human PC3 cells after 7 days by MTT assay
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[PMID: 9134750] |
Monolaurin (1.25 μg/mL, 24 hours) exhibits significant inhibitory effects on Staphylococcus aureus[3]. Monolaurin (2.5 μg/mL, over 48 hours) exhibits significant bactericidal effects on Staphylococcus aureus[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C3H/hej mice (weighing 15-18 g, intraperitoneally injected with 25 × 106 CFU Staphylococcus aureus suspension to induce infection)
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Dosage:5 mg per mouse
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Administration:Oral gavage (p.o.), once daily for 30 days, dosing started 1 week before infection
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Result:Provided 50%-70% protection against infections caused by Staphylococcus aureus.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 142-18-7
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Appearance <52°C Solid,>52°C Liquid
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Molecular Weight 274.40
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Formel C15H30O4
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Color White to off-white
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SMILES
CCCCCCCCCCCC(OCC(CO)O)=O
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Synonyms
1-Monolaurin
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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J Appl Microbiol
Inhibition of multidrug-resistant Staphylococci by sodium chlorate and select nitro- and medium chain fatty acid compounds. [Abstract]2019 May;126(5):1508-1518. PMID: 30803130 -
Lösungsmittel & Löslichkeit
DMSO : 12.5 mg/mL (45.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (4.56 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 1.25 mg/mL (4.56 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Harry G Preuss, et al. Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria. Mol Cell Biochem. 2005 Apr;272(1-2):29-34. [Content Brief]
[3]. Manohar V, et al. In vitro and in vivo effects of two coconut oils in comparison to monolaurin on Staphylococcus aureus: rodent studies. J Med Food. 2013 Jun;16(6):499-503. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6443 mL | 18.2216 mL | 36.4431 mL | 91.1079 mL |
| 5 mM | 0.7289 mL | 3.6443 mL | 7.2886 mL | 18.2216 mL | |
| 10 mM | 0.3644 mL | 1.8222 mL | 3.6443 mL | 9.1108 mL | |
| 15 mM | 0.2430 mL | 1.2148 mL | 2.4295 mL | 6.0739 mL | |
| 20 mM | 0.1822 mL | 0.9111 mL | 1.8222 mL | 4.5554 mL | |
| 25 mM | 0.1458 mL | 0.7289 mL | 1.4577 mL | 3.6443 mL | |
| 30 mM | 0.1215 mL | 0.6074 mL | 1.2148 mL | 3.0369 mL | |
| 40 mM | 0.0911 mL | 0.4555 mL | 0.9111 mL | 2.2777 mL |
Monolaurin Related Classifications
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