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Art. -Nr.: HY-181283

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MSU-43557

Name: MSU-43557
Brand: MedChemExpress
SKU: HY-181283
Price: 120.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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MSU-43557 is a Mycobacterium abscessus MmpL3 (MAB_4508) inhibitor and bactericidal agent. MSU-43557 inhibits MmpL3 function, disrupts trehalose monomycolate synthesis, and reduces biofilm-associated Mycobacterium abscessus viability. MSU-43557 exerts bactericidal activity against intracellular Mycobacterium abscessus. MSU-43557 shows low eukaryotic cytotoxicity and low Mycobacterium abscessus resistance frequency. MSU-43557 can be used for the research of mycobacterium abscessus infection.

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Reinheit: 99.74%
CAS. Nr.: 2919699-59-3
Formel: C₁₅H₁₇Cl₂N₃O
Molecular Weight:326.22

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MSU-43557 Chemical Structure

CAS. Nr.: 2919699-59-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

MSU-43557 (80 μM-0.08 nM; 3 d) potently inhibits the growth of Mycobacterium abscessus ATCC 19977 in vitro, and exhibits time-dependent bactericidal activity at a concentration of 5× MIC; meanwhile, MSU-43557 potently inhibits strains of Mycobacterium tuberculosis, Mycobacterium abscessus and Mycobacterium smegmatis, shows no activity against non-mycobacterial species within 80 μM, and displays variable inhibitory activity against clinically isolated multidrug-resistant Mycobacterium abscessus strains^[1].
MSU-43557 (0.18 nM-160 μM; 3 d) disrupts mature Mycobacterium abscessus biofilms with an EC₅₀ of 8.66 μM; it also reduces bacterial viability within biofilms, with a corresponding EC₅₀ of 0.16 μM^[1].
MSU-43557 (0.18 nM-160 μM; 3 d) kills intracellular Mycobacterium abscessus ATCC 19977 in mouse bone marrow-derived macrophages with an EC₅₀ of 0.39 μM, and exhibits low cytotoxicity toward mouse bone marrow-derived macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Mycobacterium tuberculosis strains, Mycobacterium abscessus, and Mycobacterium smegma
Concentration:

80 μM-0.08 nM
Incubation Time:

3 d
Result:

Inhibited the growth of Mycobacterium abscessus ATCC 19977 by an EC₅₀ of 1.29 μM and a MIC of 3.69 μM.
Effectively inhibited Mycobacterium tuberculosis strains (EC₅₀ value of 0.13 to 0.19 μM), Mycobacterium abscessus (EC₅₀ of 1.82 μM), and Mycobacterium smegma (EC₅₀of 2.54 μM).

Cell Cytotoxicity Assay^[1]

Cell Line:

Murine bone marrow-derived macrophages (BMMΦ)
Concentration:

200 to 0.13 μM
Incubation Time:

3 d
Result:

Resulted in a CC₅₀ of >80 μM, indicating low cytotoxicity relative to intracellular efficacy.

Chemical Information

CAS. Nr. 2919699-59-3
Appearance Solid
Molecular Weight 326.22
Formel C₁₅H₁₇Cl₂N₃O
Color White to off-white
SMILES

CC1(CCCCC1)C(NC2=NC3=CC(Cl)=C(Cl)C=C3N2)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (306.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0654 mL

15.3271 mL

30.6542 mL

5 mM

0.6131 mL

3.0654 mL

6.1308 mL

10 mM

0.3065 mL

1.5327 mL

3.0654 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Abdalla BJ, et al. Defining the Mechanism of Action and Resistance of New Mycobacterium abscessus MmpL3 Inhibitors. ACS Chem Biol. 2026 Feb 20;21(2):284-301. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0654 mL	15.3271 mL	30.6542 mL	76.6354 mL
	5 mM	0.6131 mL	3.0654 mL	6.1308 mL	15.3271 mL
	10 mM	0.3065 mL	1.5327 mL	3.0654 mL	7.6635 mL
	15 mM	0.2044 mL	1.0218 mL	2.0436 mL	5.1090 mL
	20 mM	0.1533 mL	0.7664 mL	1.5327 mL	3.8318 mL
	25 mM	0.1226 mL	0.6131 mL	1.2262 mL	3.0654 mL
	30 mM	0.1022 mL	0.5109 mL	1.0218 mL	2.5545 mL
	40 mM	0.0766 mL	0.3832 mL	0.7664 mL	1.9159 mL
	50 mM	0.0613 mL	0.3065 mL	0.6131 mL	1.5327 mL
	60 mM	0.0511 mL	0.2555 mL	0.5109 mL	1.2773 mL
	80 mM	0.0383 mL	0.1916 mL	0.3832 mL	0.9579 mL
	100 mM	0.0307 mL	0.1533 mL	0.3065 mL	0.7664 mL

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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MSU-43557

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MSU-43557 Related Classifications

HY-181283 Related Classifications

Bioz