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Art. -Nr.: HY-12645

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NCL1

NCL1 is a phenylcyclopropylamine (PCPA)-based Lysine-specific demethylase 1 (LSD1) inhibitor. NCL1 selectively inhibits LSD1 in preference to LSD2, with IC₅₀ values of 2.5 and 26 μM for LSD1 and LSD2, respectively.

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CAS. Nr.: 1196119-03-5
Formel: C₂₇H₂₉N₃O₃
Molecular Weight:443.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NCL1 Chemical Structure

CAS. Nr.: 1196119-03-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

LSD1

2.5 ± 0.5 μM (IC₅₀)

Alle Histone Demethylase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	6 μM Compound: 31	Growth inhibition of human HCT116 cells after 48 hrs by MTT assay Growth inhibition of human HCT116 cells after 48 hrs by MTT assay	[PMID: 22975593]
HCT-116	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 32931269]
HeLa	GI₅₀	13 μM Compound: 4; NCL1	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 h by MTT assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 48 h by MTT assay	10.1039/C4MD00330F
HeLa	GI₅₀	6 μM Compound: 31	Growth inhibition of human HeLa cells after 48 hrs by MTT assay Growth inhibition of human HeLa cells after 48 hrs by MTT assay	[PMID: 22975593]
HeLa	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 32931269]
KYSE-150 cell line	GI₅₀	6 μM Compound: 31	Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay Growth inhibition of human KYSE-150 cells after 48 hrs by MTT assay	[PMID: 22975593]
KYSE-150 cell line	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human KYSE150 cells after 48 hrs by MTT assay Antiproliferative activity against human KYSE150 cells after 48 hrs by MTT assay	[PMID: 32931269]
PC-3	GI₅₀	6 μM Compound: 31	Growth inhibition of human PC3 cells after 48 hrs by MTT assay Growth inhibition of human PC3 cells after 48 hrs by MTT assay	[PMID: 22975593]
PC-3	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human PC-3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells after 48 hrs by MTT assay	[PMID: 32931269]
SH-SY5Y	GI₅₀	27 μM Compound: 4; NCL1	Antiproliferative activity against human SH-SY5Y cells assessed as growth inhibition after 48 h by MTT assay Antiproliferative activity against human SH-SY5Y cells assessed as growth inhibition after 48 h by MTT assay	10.1039/C4MD00330F
SH-SY5Y	GI₅₀	6 μM Compound: 31	Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay Growth inhibition of human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 22975593]
SH-SY5Y	GI₅₀	6 μM Compound: NCL-1	Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay Antiproliferative activity against human SH-SY5Y cells after 48 hrs by MTT assay	[PMID: 32931269]

Chemical Information

CAS. Nr. 1196119-03-5
Molecular Weight 443.54
Formel C₂₇H₂₉N₃O₃
SMILES

O=C(N[C@H](C(NCC1=CC=CC=C1)=O)CCOC2=CC=CC(C3C(N)C3)=C2)C4=CC=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kakizawa T, et al. Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1193-5. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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