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Art. -Nr.: HY-137843

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NSC 80467

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NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage.

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Reinheit: 98.39%
CAS. Nr.: 101982-51-8
Formel: C₂₄H₂₂BrN₃O₅
Molecular Weight:512.35

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years

* The compound is unstable in solutions, freshly prepared is recommended.

NSC 80467 Chemical Structure

CAS. Nr.: 101982-51-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

NSC 80467, a DNA damaging agent, selectively inhibits survivin. NSC 80467 preferentially inhibits DNA synthesis and results in induction of γH2AX and pKAP1, two markers of DNA damage^[1].

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

NSC 80467 has a similar spectrum of activity against the NCI-60 cell line panel, suppresses survivin expression, shows COMPARE correlation with DNA damaging agents, preferentially inhibits DNA synthesis, and induces a DNA damage response characterized by enhanced γH2AX and pKAP1 at concentrations lower than those capable of inhibiting survivin expression^[1].
NSC 80467 (200 or 800 nM; 24 hours) inhibits surviving^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

PC3 cells
Concentration:

200 or 800 nM
Incubation Time:

24 hours
Result:

Associated with inhibition of survivin expression.

Chemical Information

CAS. Nr. 101982-51-8
Appearance Solid
Molecular Weight 512.35
Formel C₂₄H₂₂BrN₃O₅
Color Gray to brown
SMILES

O=C(C1=C2[N+](CC(C3=CC=C([N+]([O-])=O)C=C3)=O)=C(C)N1CC(C)C)C4=C(C=CC=C4)C2=O.[Br-]
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years

* The compound is unstable in solutions, freshly prepared is recommended.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (48.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9518 mL

9.7590 mL

19.5179 mL

5 mM

0.3904 mL

1.9518 mL

3.9036 mL

10 mM

0.1952 mL

0.9759 mL

1.9518 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Glaros TG, et al. The "survivin suppressants" NSC 80467 and YM155 induce a DNA damage response [published correction appears in Cancer Chemother Pharmacol. 2012 Nov;70(5):763-4]. Cancer Chemother Pharmacol. 2012;70(1):207-212. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9518 mL	9.7590 mL	19.5179 mL	48.7948 mL
	5 mM	0.3904 mL	1.9518 mL	3.9036 mL	9.7590 mL
	10 mM	0.1952 mL	0.9759 mL	1.9518 mL	4.8795 mL
	15 mM	0.1301 mL	0.6506 mL	1.3012 mL	3.2530 mL
	20 mM	0.0976 mL	0.4879 mL	0.9759 mL	2.4397 mL
	25 mM	0.0781 mL	0.3904 mL	0.7807 mL	1.9518 mL
	30 mM	0.0651 mL	0.3253 mL	0.6506 mL	1.6265 mL
	40 mM	0.0488 mL	0.2440 mL	0.4879 mL	1.2199 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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NSC 80467

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

NSC 80467 Related Classifications

HY-137843 Related Classifications