NW16
NW16 is an orally active inhibitor for STAT3 with Kd of 11.0 μM. NW16 arrests the cell cycle at S phase, induces apoptosis in HCT116, and inhibits the proliferation of cancer cell HCT116, A549, and B16 with IC50s of 0.28, 1.22, and 9.86 μM, respectively. NW16 induces the production of ROS, inhibits the PI3K/AKT signaling pathway, and thus exhibits antitumor efficacy in mouse model.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C18H12N2O5
- Molecular Weight:336.30
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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STAT3 11.0 μM (Kd) |
Chemical Information
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Molecular Weight 336.30
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Formel C18H12N2O5
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SMILES
N#C/C(C(NCCO)=O)=C\C1=CC2=C(O1)C(C3=CC=CC=C3C2=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NW16 Related Classifications
HY-169403 Related Classifications
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