ONO-1714
ONO-1714 is an orally active nitric oxide synthase inhibitor. ONO-1714 attenuates endotoxin-induced acute lung injury, reduces intestinal ischemia–reperfusion injury, represses biliary carcinogenesis.
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- CAS. Nr.: 214479-33-1
- Formel: C7H12Cl2N2
- Molecular Weight:195.09
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Peritoneal macrophage cell | IC50 |
0.82 μM
Compound: 6, ONO-1714
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Inhibition of LPS/INFgamma-induced nitric oxide production in CD-1 mouse peritoneal macrophages after 48 hrs by Griess reaction
Inhibition of LPS/INFgamma-induced nitric oxide production in CD-1 mouse peritoneal macrophages after 48 hrs by Griess reaction
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[PMID: 22703704] |
Chemical Information
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CAS. Nr. 214479-33-1
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Molecular Weight 195.09
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Formel C7H12Cl2N2
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SMILES
Cl[C@@H]1[C@@]2([H])[C@]1([H])N=C(C[C@@H]2C)N.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Mishima T, et al. Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters. Carcinogenesis. 2009 Oct;30(10):1763-7. [Content Brief]
[2]. Naito Y, et al. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide. 2004 May;10(3):170-7. [Content Brief]
[3]. Mikawa K, et al. ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg. 2003 Dec;97(6):1751-1755. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ONO-1714 Related Classifications
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