Art. -Nr.: HY-108450

Polygodial

(Synonyms: Poligodial; Tadeonal)

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Polygodial (Poligodial) is an antifungal potentiator. Polygodial is a sesquiterpene with anti-hyperalgesic properties.

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Reinheit: 99.36%
CAS. Nr.: 6754-20-7
Formel: C₁₅H₂₂O₂
Molecular Weight:234.33

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Polygodial Chemical Structure

CAS. Nr.: 6754-20-7

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Polygodial (Poligodial) is an antifungal potentiator^[1]. Polygodial is a sesquiterpene with anti-hyperalgesic properties^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	90 μM Compound: 1	Cytotoxicity against human A549 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 26360047]
A549	IC₅₀	2.5 μg/mL Compound: 10	Antitumor activity against human A549 cells Antitumor activity against human A549 cells	[PMID: 10579858]
A549	IC₅₀	2.5 μg/mL Compound: 2	Cytotoxicity against Homo sapiens (human) A549 cells Cytotoxicity against Homo sapiens (human) A549 cells	10.1016/0040-4020(95)00370-N
CHO	EC₅₀	0.059 μM Compound: 20	Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels	[PMID: 20356305]
Hs 683	GI₅₀	95 μM Compound: 1	Cytotoxicity against human Hs683 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human Hs683 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 26360047]
HT-29	IC₅₀	2.5 μg/mL Compound: 10	Antitumor activity against human HT-29 cells Antitumor activity against human HT-29 cells	[PMID: 10579858]
HT-29	IC₅₀	2.5 μg/mL Compound: 2	Cytotoxicity against Homo sapiens (human) HT-29 cells Cytotoxicity against Homo sapiens (human) HT-29 cells	10.1016/0040-4020(95)00370-N
MCF7	GI₅₀	75 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 26360047]
MCF7	IC₅₀	12.4 μM Compound: 13	Antiproliferative activity against human MCF7 cells by SRB assay Antiproliferative activity against human MCF7 cells by SRB assay	[PMID: 28274626]
P388	IC₅₀	1.2 μg/mL Compound: 10	Antitumor activity against mouse P388 cells Antitumor activity against mouse P388 cells	[PMID: 10579858]
P388	IC₅₀	1.2 μg/mL Compound: 2	Cytotoxicity against Homo sapiens (human) P388 cells Cytotoxicity against Homo sapiens (human) P388 cells	10.1016/0040-4020(95)00370-N
SK-MEL-28	GI₅₀	65 μM Compound: 1	Cytotoxicity against human SK-MEL-28 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human SK-MEL-28 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 26360047]
SK-MEL-28	IC₅₀	2.5 μg/mL Compound: 10	Antitumor activity against human SK MEL28 cells Antitumor activity against human SK MEL28 cells	[PMID: 10579858]
SK-MEL-28	IC₅₀	2.5 μg/mL Compound: 2	Cytotoxicity against Homo sapiens (human) SK-MEL-28 cells Cytotoxicity against Homo sapiens (human) SK-MEL-28 cells	10.1016/0040-4020(95)00370-N
U-373MG ATCC	GI₅₀	>100 μM Compound: 1	Cytotoxicity against human U373 cells assessed as growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human U373 cells assessed as growth inhibition incubated for 72 hrs by MTT assay	[PMID: 26360047]

In Vitro

Polygodial exhibits fungicidal activity against Saccharomyces cerevisiae, Candida albicans, and other fungal pathogens in standardized susceptibility tests (NCCLS). Polygodial (12.5 μg/mL, 3 hours) induces significant shrinkage compared to controls in Saccharomyces cerevisiae cells with the minimum fungicidal concentration (MFC) for 10⁶ CFU/mL in RPMI 1640 medium^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

S. cerevisiae cells
Concentration:

12.5 μg/mL
Incubation Time:

3 hours
Result:

Treated cells exhibited significant shrinkage compared to controls, and the organization of subcellular organelles appears either disrupted or compacted.

In Vivo

Polygodial is a sesquiterpene isolated from the barks of Drymis winteri (Winteraceae). Polygodial (0.5 to 10 mg/kg; 0.5 h; given by i.p. route to mice) induces significant, dose-related and almost complete inhibition of Acetic acid, Kaolin and Zymosan-induced abdominal constrictions. The calculated mean ID₅₀ values are 0.8, 2.1 and 2.6 mg/kg and maximal inhibitions of 90.0±3.0, 98.0±1.0 and 97.0±2.0 %, against Acetic acid, Kaolin and Zymosan, respectively. Polygodial is about 14- to 27-fold more potent than the hydroalcoholic extract (HE) at the ID₅₀ level^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Non-fasted male Swiss mice (20-30 g) or male Wistar rats (150-180 g)^[2]
Dosage:

0.1 to 10 mg/kg
Administration:

Injected i.p. 0.5 h before the injection of irritant substances
Result:

Produced significant inhibition of Acetic acid, Kaolin and Zymosan-induced writhing in mice.

Chemical Information

CAS. Nr. 6754-20-7
Appearance Solid
Molecular Weight 234.33
Formel C₁₅H₂₂O₂
Color White to off-white
SMILES

O=C[C@H]1C(C=O)=CC[C@@]2([H])C(C)(C)CCC[C@]12C
Synonyms

Poligodial; Tadeonal
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Metabolism

IFT80 and TRPA1 cooperatively regulate bone formation by calcium signaling in response to mechanical stimuli. [Abstract]

2025 May:166:156159. PMID: 39954781

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (426.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.2675 mL

21.3374 mL

42.6749 mL

5 mM

0.8535 mL

4.2675 mL

8.5350 mL

10 mM

0.4267 mL

2.1337 mL

4.2675 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (10.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. I Kubo, et al. Polygodial, an antifungal potentiator. J Nat Prod. Jan-Feb 1988;51(1):22-9. [Content Brief]

[2]. G L Mendes, et al. Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). Life Sci. 1998;63(5):369-81. [Content Brief]

[3]. C S Lunde, et al. Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2000 Jul;44(7):1943-53. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.2675 mL	21.3374 mL	42.6749 mL	106.6871 mL
	5 mM	0.8535 mL	4.2675 mL	8.5350 mL	21.3374 mL
	10 mM	0.4267 mL	2.1337 mL	4.2675 mL	10.6687 mL
	15 mM	0.2845 mL	1.4225 mL	2.8450 mL	7.1125 mL
	20 mM	0.2134 mL	1.0669 mL	2.1337 mL	5.3344 mL
	25 mM	0.1707 mL	0.8535 mL	1.7070 mL	4.2675 mL
	30 mM	0.1422 mL	0.7112 mL	1.4225 mL	3.5562 mL
	40 mM	0.1067 mL	0.5334 mL	1.0669 mL	2.6672 mL
	50 mM	0.0853 mL	0.4267 mL	0.8535 mL	2.1337 mL
	60 mM	0.0711 mL	0.3556 mL	0.7112 mL	1.7781 mL
	80 mM	0.0533 mL	0.2667 mL	0.5334 mL	1.3336 mL
	100 mM	0.0427 mL	0.2134 mL	0.4267 mL	1.0669 mL

Keywords

Polygodial

1 Cited Publications

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Polygodial

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Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

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Complete Stock Solution Preparation Table

Polygodial

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Covalent Screening Library

Antifungal Compound Library

Terpenoids Library

Traditional Chinese Medicine Active Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Marine-Sourced Natural Product Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Mongolian Medicine Compound Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Polygodial

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Polygodial Related Classifications

HY-108450 Related Classifications