PU-20F
PU-20F is a Hsp90 inhibitor with an EC50 of 6.8 μM. PU-20F competes with Geldanamycin (HY-15230) for binding to Hsp90 and regulates the function of this molecular chaperone. PU-20F induces the degradation of oncogenic Her2 tyrosine kinase. PU-20F blocks the growth of breast cancer cells. PU-20F can be used in breast cancer-related research.
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- CAS. Nr.: 422508-29-0
- Formel: C20H24FN5O4
- Molecular Weight:417.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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HSP90 6.8 μM (EC50) |
PU-20F (compound 59) competes with geldanamycin for binding to purified Hsp90 protein with an EC50 of 6.8 μM[1].
PU-20F (72 h) inhibits the growth of MCF-7 human breast cancer cells with an IC50 of 23 μM[1].
PU-20F induces degradation of Her2 tyrosine kinase in MCF-7 human breast cancer cells with an IC50 of 20 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 422508-29-0
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Molecular Weight 417.44
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Formel C20H24FN5O4
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SMILES
FC=1N=C(N)C=2N=C(N(C2N1)CC3OCCC3)CC4=CC(OC)=C(OC)C(OC)=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PU-20F Related Classifications
HY-121706 Related Classifications
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