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Art. -Nr.: HY-113995A

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rel-(-)-Vesamicol

(Synonyms: rel-(-)-AH5183)

rel-(-)-Vesamicol (rel-(-)-AH5183) is the racemate of (-)-Vesamicol. (-)-Vesamicol is a vesicular acetylcholine transporter inhibitor. (-)-Vesamicol reversibly and non-competitively inhibits the transport of acetylcholine into circulating synaptic vesicles and blocks the activity of vesicular acetylcholine transporters in medial amygdala neurons. (-)-Vesamicol is applicable to research related to central precocious puberty.

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CAS. Nr.: 115362-28-2
Formel: C₁₇H₂₅NO
Molecular Weight:259.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

rel-(-)-Vesamicol Chemical Structure

CAS. Nr.: 115362-28-2

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Biologische Aktivität

Beschreibung

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In Vivo

rel-(-)-Vesamicol (20 mmol; stereotactic injection) significantly delays precocious puberty onset induced by sexual content stimuli, reduces the serum LH/FSH ratio, and decreases kisspeptin expression in the ARC of female Sprague-Dawley rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 115362-28-2
Molecular Weight 259.39
Formel C₁₇H₂₅NO
SMILES

O[C@H]1[C@H](N2CCC(C3=CC=CC=C3)CC2)CCCC1
Synonyms

rel-(-)-AH5183
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Searl T, et al. Acetylcholine recycling and release at rat motor nerve terminals studied using (-)-vesamicol and troxpyrrolium. The Journal of physiology. 1991 Dec;444:99-116. [Content Brief]

[2]. Shen Y, et al. Early Exposure of an Infantile Rat to Sex-Related Content Induces Precocious Puberty by Activation of Cholinergic Neurons in the Amygdala and KNDy Neurons in the Arcuate Nucleus. ACS omega. 2025 Jul 22;10(28):30327-30334. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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rel-(-)-Vesamicol

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rel-(-)-Vesamicol Related Classifications

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