SB-587094
SB-587094 is a MetAP-2 inhibitor. SB-587094 inhibits cobalt- and manganese-containing hMetAP2. SB-587094 inhibits endothelial cell proliferation. SB-587094 is applicable to cancer-related research.
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- CAS. Nr.: 949142-44-3
- Formel: C16H18N4S2
- Molecular Weight:330.47
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
150 nM
Compound: 102
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Growth inhibition of HUVEC cells by XTT assay
Growth inhibition of HUVEC cells by XTT assay
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[PMID: 17636946] |
SB-587094 (Thiophene 102) exhibits inhibitory activity against recombinant human cobalt-containing MetAP-2, with a Ki,app of 2 nM[2].
SB-587094 inhibits recombinant human manganese-containing MetAP-2 with an apparent inhibition constant (Ki,app) of 1500 nM[2].
SB-587094 (72 h) inhibits the proliferation of human umbilical vein endothelial cells with an IC50 of 150 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 949142-44-3
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Molecular Weight 330.47
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Formel C16H18N4S2
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SMILES
CC(C)C1=C(C=CC=C1)NC2=NN=C(SCC3=CC=CS3)N2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Heinrich T, et al. Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors. J Med Chem. 2019;62(10):5025-5039. [Content Brief]
[2]. Marino JP Jr, et al. Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem. 2007;50(16):3777-3785. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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