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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Art. -Nr.: HY-176531
CAS. Nr.: 3049804-05-6
Antiviral agent 69 (Compound L2) is a capsid protein residue THR155-targeting inhibitor of phytoviral intercellular traffic. Antiviral agent 69 has an excellent antiviral activity against Potato virus Y (PVY) with an EC50 of 128.10 μg/mL for inactivation effect. Antiviral agent 69 effectively decreases viral accumulation in host plant Nicotiana benthamiana, promising for novel pesticide research and development .
Art. -Nr.: HY-176554
CAS. Nr.: 3084814-46-7
Forschungsgebiete:
sEH-IN-21 is an orally active sEH inhibitor with IC50s of 0.1 nM for hsEH and msEH. sEH-IN-21 potently inhibits NF-κB signaling pathways. sEH-IN-21 shows a strong anti-inflammatory activity, decreases the release of IL-6 and TNF-α and maintained the integrity of the intestinal barrier. sEH-IN-21 can be used for the study of inflammatory bowel disease (IBD) .
Art. -Nr.: HY-179443
CAS. Nr.: 3092446-09-5
SOS1-IN-25 is an SOS1 inhibitor. SOS1-IN-25 exhibits inhibitory activity against KRAS G12C/SOS1 complex formation (IC50 = 11.11 nM). SOS1-IN-25 leads to a dose-dependent decrease in pERK levels. SOS1-IN-25 can be used for the study of leukemia .
Art. -Nr.: HY-183919
CAS. Nr.: 2237229-78-4
Forschungsgebiete:
ACC2-IN-1 is an orally active, selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), with an IC50 of 1.9 nM against human targets. ACC2-IN-1 acts as a reducing agent to decrease malonyl-CoA levels in skeletal muscle and exhibits a favorable CYP450 inhibition profile. ACC2-IN-1 can be used in the research of type 2 diabetes .
Art. -Nr.: HY-186178
CAS. Nr.: 2766686-04-6
Target:
Forschungsgebiete:
CD38-IN-6 is an orally active CD38 inhibitor. CD38-IN-6 regulates NAD + metabolite levels in the liver of aged obese mice by increasing NAD + and NMN levels, and decreasing NAM and ADPR levels. CD38-IN-6 alleviates inflammatory responses in mice. CD38-IN-6 can be used for research related to obesity and inflammation .
Art. -Nr.: HY-189691
MIH-36 is a VEGFR-2 modulator and anticancer agent. MIH-36 decreases VEGFR-2 surface expression in cells while upregulating VEGFR-2 mRNA. MIH-36 induces Apoptosis. MIH-36 exhibits selective anticancer activity against luminal and triple-negative breast cancer. MIH-36 can be used for research on breast cancer .
Art. -Nr.: HY-19150
CAS. Nr.: 139681-18-8
Synonyms: FOX-988
Target:
Forschungsgebiete:
SDZ-FOX-988 (FOX-988) is an orally active antidiabetic agent. SDZ-FOX-988 sequesters mitochondrial coenzyme A to inhibit carnitine palmitoyltransferase II. SDZ-FOX-988 induces mitochondrial injury. SDZ-FOX-988 causes a decrease in serum β-hydroxybutyrate or glucose. SDZ-FOX-988 can be used in the research of type 2 diabetes .
Art. -Nr.: HY-203233
CAS. Nr.: 126111-99-7
Target:
Forschungsgebiete:
4-(Dimethylamino)phenol is a potent cyanide antidote. 4-(Dimethylamino)phenol increases the extracellular lactate dehydrogenase (LDH) without markedly affecting gluconeogenesis. 4-(Dimethylamino)phenol cannot decreases the ATP content until the membrane becomes permeable to LDH. 4-(Dimethylamino)phenol’s toxicity is related to its reaction with glutathione and formation of covalent complexes, leading to impaired cellular function .
Art. -Nr.: HY-A0060R
CAS. Nr.: 59937-28-9
Synonyms: NKK 105 (Standard)
Target:
Forschungsgebiete:
Malotilate (Standard) is the analytical standard of Malotilate. This product is intended for research and analytical applications. Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .
Art. -Nr.: HY-B0185BR
CAS. Nr.: 6108-05-0
Synonyms: Lignocaine hydrochloride hydrate (Standard)
Forschungsgebiete:
Lidocaine (hydrochloride hydrate) (Standard) is the analytical standard of Lidocaine (hydrochloride hydrate). This product is intended for research and analytical applications. Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia .
Forschungsgebiete:
Lidocaine (Standard) is the analytical standard of Lidocaine. This product is intended for research and analytical applications. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .
Art. -Nr.: HY-B0185S2
CAS. Nr.: 1215823-29-2
Synonyms: Lignocaine-d6
Art. -Nr.: HY-B1452R
CAS. Nr.: 156897-06-2
Synonyms: ML-3000 (Standard)
Target:
Forschungsgebiete:
Licofelone (Standard) is the analytical standard of Licofelone. This product is intended for research and analytical applications. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins .
Art. -Nr.: HY-N0831R
CAS. Nr.: 18085-97-7
Category:
Plant Flavonoids Artemisia vestita Wall. ex Bess. Extract Phenols Compositae/Asteraceae Extract Disease Research Fields Inflammation/Immunology
Target:
Art. -Nr.: HY-N20390
Target:
Art. -Nr.: HY-N21956
CAS. Nr.: 96657-95-3
Category:
Alkaloids Plant Pyrrole Alkaloids Compositae/Asteraceae Extract Senecio latifolius DC. Extract
Target:
Art. -Nr.: HY-P10617
CAS. Nr.: 624735-23-5
Target:
Forschungsgebiete:
Art. -Nr.: HY-P10798
CAS. Nr.: 2883634-40-8
Synonyms: LY-3841136
Target:
Forschungsgebiete:
Eloralintide (LY-3841136) is an amylin receptor agonist with human AMY1R EC50 23.9 pM and human AMY3R EC50 253.8 pM. Eloralintide induces decreased appetite, reduced food intake, body weight and fat mass loss, prolonged plasma calcium 2+ reduction, and weak conditioned taste avoidance. Eloralintide can be used for the research of obesity .
Art. -Nr.: HY-P2260A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
