Selank
Based on 1 Customer Validation
Selank (Selanc; TP-7) is a GABAA receptor modulator with anxiolytic activity. Selank allosterically modulates the specific binding of GABA to GABAA receptors and alters the affinity of endogenous ligands for these receptors. Selank reduces elevated anxiety levels, attenuates stress-induced exacerbation of anxiety, and produces a synergistic anxiolytic effect with diazepam. Selank can be used in the research of anxiety disorders.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.80%
- CAS. Nr.: 129954-34-3
- Formel: C33H57N11O9
- Molecular Weight:751.87
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
In Vivo
Selank (300 μg/kg; i.n.; once daily; 14 days) significantly mitigates stress-induced anxiety-related behavioral deterioration in UCMS-exposed rats compared to saline-treated controls[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, average weight 400 g)[1]
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Dosage:300 μg/kg
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Administration:i.n.; once daily; 14 days
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Result:Decreased median time spent in open arms from 40.2 s to 12.2 s.
Increased median time spent in closed arms from 124.9 s to 147.7 s.
Decreased median number of hanging events from open arms from 7 to 5.
Decreased median number of squares crossed minimally from 36 to 30.
Maintained median number of rears at 9.5.
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Animal Model:Wistar rats (male, average weight 400 g, UCMS-induced anxiety)[1]
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Dosage:300 μg/kg
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Administration:i.n.; once daily; 14 days (concurrent with UCMS exposure)
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Result:Decreased median time spent in open arms from 64.7 s (41.7-79.4 s IQR) to 15.5 s (7-26.6 s IQR).
Increased median time spent in closed arms from 104.7 s to 139.9 s.
Decreased median number of hanging events from open arms from 9 to 4.5.
Decreased median number of squares crossed from 39 to 22.
Decreased median number of rears from 6.5 to 5.5.
Exhibited magnitude of anxiety indicator changes similar to non-stressed rats administered Selank, and significantly less severe than changes observed in UCMS-exposed rats administered saline.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 129954-34-3
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Appearance Solid
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Molecular Weight 751.87
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Formel C33H57N11O9
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Color White to off-white
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Synonyms
Selanc; TP-7
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Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
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Sequence Shortening
TKPRPGP
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (66.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (6.65 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (6.65 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.3300 mL | 6.6501 mL | 13.3002 mL | 33.2504 mL |
| 5 mM | 0.2660 mL | 1.3300 mL | 2.6600 mL | 6.6501 mL | |
| 10 mM | 0.1330 mL | 0.6650 mL | 1.3300 mL | 3.3250 mL | |
| 15 mM | 0.0887 mL | 0.4433 mL | 0.8867 mL | 2.2167 mL | |
| 20 mM | 0.0665 mL | 0.3325 mL | 0.6650 mL | 1.6625 mL | |
| 25 mM | 0.0532 mL | 0.2660 mL | 0.5320 mL | 1.3300 mL | |
| 30 mM | 0.0443 mL | 0.2217 mL | 0.4433 mL | 1.1083 mL | |
| 40 mM | 0.0333 mL | 0.1663 mL | 0.3325 mL | 0.8313 mL | |
| 50 mM | 0.0266 mL | 0.1330 mL | 0.2660 mL | 0.6650 mL | |
| 60 mM | 0.0222 mL | 0.1108 mL | 0.2217 mL | 0.5542 mL |
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