Senktide TFA
Based on 3 publication(s) in Google Scholar
Senktide TFA is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50=0.5-3 nM). Senktide TFA less potently agonizes the NK1 receptor (EC50=35 µM). Senktide TFA is promising for research of neurological disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C42H56F3N7O13S
- Molecular Weight:955.99
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Senktide TFA
More
Biologische Aktivität
|
NK3R 0.5-3 nM (EC50) |
NK1R 35 μM (EC50) |
Chemical Information
-
Molecular Weight 955.99
-
Formel C42H56F3N7O13S
-
Sequence
Suc-Asp-Phe-{Me-Phe}-Gly-Leu-Met-NH2
-
Sequence Shortening
Suc-DF-{Me-Phe}-GLM-NH2
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Neuron
2026 Jan 8:S0896-6273(25)00927-4. PMID: 41512855 -
Protein Cell
Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice. [Abstract]2024 Apr 1;15(4):261-284. PMID: 38011644 -
FASEB J
Neurokinin 3 receptor agonist senktide stimulates GnRH release in isolated hypogonadotropic hypogonadism mice. [Abstract]2025 Mar 31;39(6):e70498. PMID: 40135619
Reinheit & Dokumentation
Verweise
[1]. Byk G, et al. Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. J Med Chem. 1996 Aug 2;39(16):3174-8. [Content Brief]
[2]. Sarau HM, et al. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J Pharmacol Exp Ther. 1997 Jun;281(3):1303-11. [Content Brief]
[3]. Harrison T, et al. High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template. Bioorg Med Chem Lett. 1998 Jun 2;8(11):1343-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Senktide TFA Related Classifications
HY-W755425 Related Classifications
Powered by Bioz