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Simridarlimab

(Synonyms: IBI-322)
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Simridarlimab (IBI-322) is a bispecific antibody targeting PD-L1 and CD47. Simridarlimab attenuates CD47 activity in monovalent binding and blockes PD-L1 activity in bivalent binding. Simridarlimab selectively binds to CD47+PD-L1+ tumor cells, effectively inhibits CD47-SIRPα signal and triggered strong tumor cell phagocytosis in vitro.

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  • Reinheit: 99.81%
  • CAS. Nr.: 2378862-90-7
  • Molecular Weight:125.734 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Simridarlimab
  • Experimental Validation Results for Simridarlimab
  • Experimental Validation Results for Simridarlimab
  • Experimental Validation Results for Simridarlimab
  • Simridarlimab Chemical Structure
    Simridarlimab Chemical Structure
CAS. Nr.: 2378862-90-7
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Simridarlimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    (G1_L-kappa)_VH-VH-h-CH2-CH3

  • 1/16

    Immobilized CD47 Protein, Human (HEK293, HY-P72917) can bind Simridarlimab. The EC50 for this effect is 134.7 ng/mL.

  • 1/16

    Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Simridarlimab. The EC50 for this effect is 188.8 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD47 (red) with Simridarlimab (HY-P99903). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Simridarlimab Chemical Structure
    1/16
  • Simridarlimab
  • Immobilized CD47 Protein, Human (HEK293, HY-P72917) can bind Simridarlimab. The EC50 for this effect is 134.7 ng/mL.
  • Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Simridarlimab. The EC50 for this effect is 188.8 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD47 (red) with Simridarlimab (HY-P99903). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • (G1_L-kappa)_VH-VH-h-CH2-CH3