Sodium thiosulfate (98%)
Based on 1 Customer Validation
Sodium thiosulfate (Sodium hyposulfite) is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Assay : 98.30%
- CAS. Nr.: 7772-98-7
- Formel: Na2S2O3
- Molecular Weight:158.11
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Speicherung:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-108775A
Sodium thiosulfate (99%, water≤1.0%)Antioxidant -
HY-Y0344D
Sodium chloride, for cell cultureBiochemical Assay Reagent -
HY-Y0406E
Calcium chloride anhydrous, for cell cultureCalcium Chloride -
HY-Y0283
Potassium iodide ,meet Ch.PBiochemical Reagent -
HY-23539C
Sodium thiosulfate pentahydrate (GR,≥99.5%)Biochemical Reagent -
HY-Y1673
Potassium bromide, 99%Anticonvulsant/Sedative -
HY-Y1267D
Magnesium sulfate, for cell cultureAnti-Inflammatory Agent -
HY-Y1267
Magnesium sulfateAnti-Inflammatory Agent -
HY-ER013C
Sodium carbonate anhydrous, 99.8%Biochemical Reagent -
HY-Y0344I
Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% AlBiochemical Reagent
Biologische Aktivität
Beschreibung
In Vitro
Sodium thiosulfate (1.2-120 μM; 48 h) does not affect MCF-7 viability[1].
Sodium thiosulfate (3 mM; 8 h) stimulates proliferation of human umbilical vein endothelial cells (HUVEC)[2].
Sodium thiosulfate (0.2-25 mM; 1-7 days) dose-dependently inhibits mineralization of murine joint chondrocytes[3].
Sodium thiosulfate (1-500 μM; 8 h) reduces LPS/IFNγ-induced release of TNFα and IL-6 in microglia[4].
Sodium thiosulfate (0.1-10 mM; 48 h) does not attenuate the anticancer activity of Doxorubicin (HY-15142A) in human breast cancer MCF-7 cells and human cervical cancer HeLa cells[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Sodium thiosulfate (0.4 g/kg; i.p.; three times per week) reduces the volume and crystal content of new periarticular calcific deposits, attenuates tibial and femoral cartilage damage and proteoglycan loss, and shows a significant positive correlation between the volume of new mineralized structures and tibial cartilage degradation score in menisectomy-induced osteoarthritis model of female C57BL/6 mice[3].
Sodium thiosulfate (2 g/kg; intraperitoneal injection, 0 and 12 h after LPS challenge; 0.5 g/kg; i.v., 10 min after CLP) attenuates LPS or CLP-induced acute lung injury in male C57BL6J mice by inhibiting lung inflammation, reducing lung permeability, and suppressing NFκB activation[5].
Sodium thiosulfate (2-3 g/kg; once daily) inhibits tumor growth and EMT process by the Wnt/β-catenin signaling pathway in nude mice xenografted with B16 cells[8].
Sodium thiosulfate (100-750 mg/kg; i.p.) reduces brain inflammation induced by systemic lipopolysaccharide administration in female C57BL/6J mice by decreasing IL-1β, COX-2, Iba-1, and TSPO levels [9].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 7772-98-7
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Appearance Solid
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Molecular Weight 158.11
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Formel Na2S2O3
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Color White to off-white
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SMILES
[Na][Na].O=S(=O)=S=O
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Synonyms
Sodium hyposulfite (98%)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Lösungsmittel & Löslichkeit
In Vitro:
H2O : ≥ 100 mg/mL (632.47 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Ota A, et al. The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death. Pharmacol Rep. 2021 Jun;73(3):847-857. [Content Brief]
[2]. Macabrey D, et al. Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization. Front Cardiovasc Med. 2022 Oct 3;9:965965. [Content Brief]
[3]. Nasi S, et al. Sodium Thiosulfate Prevents Chondrocyte Mineralization and Reduces the Severity of Murine Osteoarthritis. PLoS One. 2016 Jul 8;11(7):e0158196. [Content Brief]
[4]. Lee M, et al. Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases. J Neuroinflammation. 2016 Feb 8;13:32. [Content Brief]
[5]. Sakaguchi M, et al. Sodium thiosulfate attenuates acute lung injury in mice. Anesthesiology. 2014 Dec;121(6):1248-57. [Content Brief]
[6]. Mizuta Y, et al. Sodium thiosulfate prevents doxorubicin-induced DNA damage and apoptosis in cardiomyocytes in mice. Life Sci. 2020 Sep 15;257:118074. [Content Brief]
[7]. Bijarnia RK, et al. Sodium thiosulfate ameliorates oxidative stress and preserves renal function in hyperoxaluric rats. PLoS One. 2015 Apr 30;10(4):e0124881. [Content Brief]
[8]. Wang D, et al. Sodium thiosulfate inhibits epithelial-mesenchymal transition in melanoma via regulating the Wnt/β-catenin signaling pathway. J Dermatol Sci. 2023 Feb;109(2):89-98. [Content Brief]
[9]. Acero G, et al. Sodium thiosulphate attenuates brain inflammation induced by systemic lipopolysaccharide administration in C57BL/6J mice. Inflammopharmacology. 2017 May 19. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 6.3247 mL | 31.6236 mL | 63.2471 mL | 158.1178 mL |
| 5 mM | 1.2649 mL | 6.3247 mL | 12.6494 mL | 31.6236 mL | |
| 10 mM | 0.6325 mL | 3.1624 mL | 6.3247 mL | 15.8118 mL | |
| 15 mM | 0.4216 mL | 2.1082 mL | 4.2165 mL | 10.5412 mL | |
| 20 mM | 0.3162 mL | 1.5812 mL | 3.1624 mL | 7.9059 mL | |
| 25 mM | 0.2530 mL | 1.2649 mL | 2.5299 mL | 6.3247 mL | |
| 30 mM | 0.2108 mL | 1.0541 mL | 2.1082 mL | 5.2706 mL | |
| 40 mM | 0.1581 mL | 0.7906 mL | 1.5812 mL | 3.9529 mL | |
| 50 mM | 0.1265 mL | 0.6325 mL | 1.2649 mL | 3.1624 mL | |
| 60 mM | 0.1054 mL | 0.5271 mL | 1.0541 mL | 2.6353 mL | |
| 80 mM | 0.0791 mL | 0.3953 mL | 0.7906 mL | 1.9765 mL | |
| 100 mM | 0.0632 mL | 0.3162 mL | 0.6325 mL | 1.5812 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium thiosulfate (98%) Related Classifications
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