SPC-180002
SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway.
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- CAS. Nr.: 2170274-53-8
- Formel: C18H23NO4
- Molecular Weight:317.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-B0150
Nicotinamide -
HY-B0150R
Nicotinamide (Standard) -
HY-13515
Sirtinol -
HY-100591
SirReal2 -
HY-100732
Cambinol -
HY-101278
Thiomyristoyl -
HY-100591R
SirReal2 (Standard) -
HY-123194
SIRT2/6-IN-1 -
HY-B0150G
Nicotinamide (GMP) -
HY-13515R
Sirtinol (Standard) -
HY-100732R
Cambinol (Standard) -
HY-101278R
Thiomyristoyl (Standard)
Biologische Aktivität
Beschreibung
IC50 & Target
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SIRT1 1.13 ± 0.3 μM (IC50) |
SIRT3 5.41 ± 4.8 μM (IC50) |
In Vitro
SPC-180002 (0-5 μM, 24 h) inhibits cell cycle progression via p21 accumulation, which causes subsequent cellular senescence[1].
SPC-180002 dose not induce apoptosis and autophagy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Five weeks female athymic nude mice (BALB/c)[1]
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Dosage:1 mg/kg or 5 mg/kg
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Administration:i.p., twice a week
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Result:Significantly impeded tumor progression. The gain of tumor volume in SPC-180002-treated mice was significantly reduced by 48% at the low dose (1 mg/kg) and by 52% at the high dose (5 mg/kg), compared to vehicle-treated mice.
Chemical Information
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CAS. Nr. 2170274-53-8
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Molecular Weight 317.38
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Formel C18H23NO4
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SMILES
O=C(C(CN(CCC1=CC=CC=C1)CC(C(OC)=O)=C)=C)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SPC-180002 Related Classifications
HY-155784 Related Classifications
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