Supradamal
Supradamal is a peptidyl-prolyl cis-trans isomerase (PPIase) inhibitor with an IC50 of 83 nM against *Plasmodium falciparum* and an IC50 of 75 nM against *Plasmodium vivax*. Supradamal inhibits the development, maturation and in vitro growth of *Plasmodium falciparum* trophozoites. Supradamal is applicable to malaria-related research.
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- CAS. Nr.: 71458-51-0
- Formel: C17H21N3O2
- Molecular Weight:299.37
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
Beschreibung
In Vitro
Supradamal inhibits the growth of Plasmodium falciparum in human red blood cells, including the development of trophozoites[1].
Supradamal (Compound 4a) inhibits the peptidyl-prolyl isomerase activity of purified Plasmodium falciparum FKBD35, with an IC50 of 83 nM[3].
Supradamal inhibits the peptidyl-prolyl isomerase activity of purified Plasmodium vivax FKBD35 with an IC50 of 75 nM[3].
Supradamal (48 h) inhibits the growth of *Plasmodium falciparum* strain 3D7 in vitro by specifically interfering with the development of the trophozoite stage, while exerting no effect on ring-stage parasites[3].
Supradamal (500 nM; 4-16 h) specifically inhibits the development of trophozoite-stage parasites of the Plasmodium falciparum 3D7 strain, with no effect on ring-stage or schizont-stage parasites[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 71458-51-0
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Appearance Solid
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Molecular Weight 299.37
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Formel C17H21N3O2
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Color White to off-white
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SMILES
O=C(C1=CC=NC=C1)NNC(C23CC4CC(C3)CC(C2)C4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[2]. Rasch J, et al. Novel Cycloheximide Derivatives Targeting the Moonlighting Protein Mip Exhibit Specific Antimicrobial Activity Against Legionella pneumophila. Frontiers in bioengineering and biotechnology. 2015;3:41. [Content Brief]
[3]. Harikishore A, et al. Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. ACS medicinal chemistry letters. 2013 Nov 14;4(11):1097-101. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Supradamal Related Classifications
HY-183450 Related Classifications
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