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Art. -Nr.: HY-125594

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T-1095A

T-1095A is an active metabolite of T-1095 (HY-106158) (an SGLT inhibitor).

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CAS. Nr.: 209746-56-5
Formel: C₂₄H₂₆O₉
Molecular Weight:458.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

T-1095A Chemical Structure

CAS. Nr.: 209746-56-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

T-1095A is an active metabolite of T-1095 (HY-106158) (an SGLT inhibitor)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	211 nM Compound: 2, T-1095A	Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation	[PMID: 18260618]
CHO	EC₅₀	6.6 nM Compound: 2, T-1095A	Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation	[PMID: 18260618]
CHO	IC₅₀	240 nM Compound: 1, T1095A	Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scintillation counting Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scintillation counting	[PMID: 20690635]
CHO	IC₅₀	5.2 nM Compound: 1, T1095A	Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scintillation counting Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scintillation counting	[PMID: 20690635]
CHO-K1	IC₅₀	0.011 μM Compound: 1	Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells	[PMID: 16198559]
CHO-K1	IC₅₀	0.139 μM Compound: 1	Inhibitory activity towards human SGLT1 expressed in CHO-K1 cells Inhibitory activity towards human SGLT1 expressed in CHO-K1 cells	[PMID: 16198559]
CHO-K1	IC₅₀	0.011 μM Compound: 1	Inhibitory activity against SGLT2 expressed in CHO-K1 cells Inhibitory activity against SGLT2 expressed in CHO-K1 cells	[PMID: 16380256]
CHO-K1	IC₅₀	0.139 μM Compound: 1	Inhibitory activity against SGLT1 expressed in CHO-K1 cells Inhibitory activity against SGLT1 expressed in CHO-K1 cells	[PMID: 16380256]
L6	IC₅₀	>10000 nM Compound: 1, T1095A	Inhibition of GLUT1-mediated [3H]2-deoxy-glucose uptake in rat L6 cells after 15 mins by liquid scintillation counting Inhibition of GLUT1-mediated [3H]2-deoxy-glucose uptake in rat L6 cells after 15 mins by liquid scintillation counting	[PMID: 20690635]

Chemical Information

CAS. Nr. 209746-56-5
Molecular Weight 458.46
Formel C₂₄H₂₆O₉
SMILES

O=C(C1=C(O)C=C(C)C=C1O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)CCC3=CC=C4OC=CC4=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Oku A, et al. T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes. 1999 Sep;48(9):1794-800. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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