TCS 2510
Based on 1 Customer Validation
TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.30%
- CAS. Nr.: 346673-06-1
- Formel: C21H29N5O2
- Molecular Weight:383.49
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Speicherung:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
EP4[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
2.5 nM
Compound: 19a
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EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor
EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor
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[PMID: 12643927] |
| HEK293 | IC50 |
1.4 nM
Compound: 19a
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Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells
Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells
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[PMID: 12643927] |
TCS 2510 (0.001~100 μM; GLUTag cells) stimulates glucagon like peptide 1 secretion. TCS2510 activates the Gas signaling pathway. TCS 2510 (10 μM; 2~24 h; GLUTag cells) increases the Gcg mRNA expression levels. TCS 2510 produces a concentration dependent increase in cAMP levels in GLUTag cells with EC50 of 20 nM and the maximal stimulation of 60 % over the basal cAMP levels. The decrease in cell impedance in GLUTag cells observed with TCS 2510 is concentration dependent with IC50 of 15 nM. TCS 2510 produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels[1].
TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levels[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:0.1~10 mg/kg
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Administration:P.o.
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Result:Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.
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Animal Model:Mice[1]
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Dosage:10 mg/kg
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Administration:P.o.
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Result:Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.
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Animal Model:Mice[1]
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Dosage:1~10 mg/kg
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Administration:P.o.
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Result:Afforded a significant elevation in plasma glucagon like peptide 2 levels.
Chemical Information
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CAS. Nr. 346673-06-1
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Appearance Liquid
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Molecular Weight 383.49
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Formel C21H29N5O2
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Color Colorless to light yellow
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SMILES
O=C1N(CCCCCCC2=NNN=N2)[C@@H](/C=C/[C@@H](O)CC3=CC=CC=C3)CC1
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Synonyms
CAY10598
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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