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Tebotelimab

(Synonyms: MGD-013)
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Tebotelimab (MGD-013) is a humanized IgG4κ bispecific PD-1/LAG-3 dual-affinity re-targeting (DART) antibody. Tebotelimab binds cell-surface expressed PD-1 and LAG-3 with EC50s of 1.65 nM and 0.41 nM in NS0 cells, respectively. Tebotelimab blocks PD-1/PD-L1, PD-1/PD-L2 and LAG-3/HLA (MHC-II) interactions and PD-1 signaling. Tebotelimab restores exhausted T-cell responses and and enhances antitumour immunity.

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  • Reinheit: 99.52%
  • CAS. Nr.: 2245725-04-4
  • Molecular Weight:166.7 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tebotelimab
  • Experimental Validation Results for Tebotelimab
  • Experimental Validation Results for Tebotelimab
  • Experimental Validation Results for Tebotelimab
  • Tebotelimab Chemical Structure
    Tebotelimab Chemical Structure
CAS. Nr.: 2245725-04-4
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Tebotelimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    [V-kappa'-VH-h-CH2-CH3_V-kappa-VH']2

  • 1/16

    Immobilized Tebotelimab can bind Human PD-1 Protein (ECD, His Tag). The EC50 for this effect is 0.413 ng/mL.

  • 1/16

    Immobilized Tebotelimab can bind Human LAG-3 Protein (ECD, His Tag). The EC50 for this effect is 0.423 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling LAG-3 (red) with Tebotelimab (HY-P99573). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control.

  • Tebotelimab Chemical Structure
    1/16
  • Tebotelimab
  • Immobilized Tebotelimab can bind Human PD-1 Protein (ECD, His Tag). The EC50 for this effect is 0.413 ng/mL.
  • Immobilized Tebotelimab can bind Human LAG-3 Protein (ECD, His Tag). The EC50 for this effect is 0.423 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling LAG-3 (red) with Tebotelimab (HY-P99573). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control.
  • [V-kappa'-VH-h-CH2-CH3_V-kappa-VH']2