country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-179132

Copy Link Print Information

TN-101

TN-101 is an orally active NLRP3 inhibitor (IC₅₀ = 29.8 nM). TN-101 can be used for the study of obesity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₈H₂₀FIN₂O₃
Molecular Weight:458.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (244 KB)

TN-101 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

TN-101 is an orally active NLRP3 inhibitor (IC₅₀ = 29.8 nM). TN-101 can be used for the study of obesity^[1].

IC₅₀ & Target

NLRP3

29.8 nM (IC₅₀)

Alle NOD-like Receptor (NLR) Isoform-spezifische Produkte anzeigen :

In Vitro

TN-101 (2 h) can effectively inhibit the secretion of IL-1β (IC₅₀ = 5.58 nM) by THP-1 cells, under Lipopolysaccharides (HY-D1056) (LPS)/Nigericin (HY-127019) stimulation^[1].
TN-101 (0.3 nM-6 μM, 1 h) can dose-dependently inhibit the secretion of IL-1β (IC₅₀ = 5.97 nM) and IL-18 (IC₅₀ = 12.2 nM) in THP-1 cells induced by Palmitic acid (HY-N0830)-BSA complex^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TN-101 (1-10 mg/kg, p.o., twice daily, 15-28 days) does not affect the body weight of Diet-induced obese (DIO) mice, indicating that only NLRP3 inhibitors that can enter the central nervous system and reach effective doses can induce sustained weight loss in DIO mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Diet-induced obese (DIO) and Normal chow (NC)-fed lean mice^[1].
Dosage:

1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:

P.o., twice daily for 15 days
Result:

Showed no effect on the weight of DIO and NC lean mice.

Animal Model:

Diet-induced obese (DIO) and Normal chow (NC)-fed lean mice^[1].
Dosage:

1 mg/kg
Administration:

P.o., twice daily for 28 days
Result:

Showed no effect on the weight of DIO and NC lean mice.

Chemical Information

Molecular Weight 458.27
Formel C₁₈H₂₀FIN₂O₃
SMILES

O[C@]1(C[C@H](C1)NC(CN2C[C@@]3(C4=C(C2=O)C=CC(I)=C4)C[C@H]3F)=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.