USP10-IN-3
Based on 1 Customer Validation
USP10-IN-3 (compound D1) is a potent USP10 inhibitor with an IC50 value of 7.2 µM. USP10-IN-3 inhibits cell proliferation. USP10-IN-3 induces apoptosis and cell cycle arrest at S-phase.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.00%
- CAS. Nr.: 3059565-11-3
- Formel: C29H25ClN4O3
- Molecular Weight:512.99
-
Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Aging Compound Library
HY-L034
-
Ubiquitination Compound Library
HY-L050
-
Metabolic Enzyme Compound Library
HY-L146
-
Protease Inhibitor Library
HY-L147
-
Highly Selective Inhibitors Library
HY-L158
-
Highly Selective Activators Library
HY-L159
-
Cell Death Library
HY-L162
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
Biologische Aktivität
|
USP10 7.2 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Bel-7402 | IC50 |
2.3 μM
Compound: D1
|
Antiproliferative activity against human Bel-7402 cells by CCK-8 method
Antiproliferative activity against human Bel-7402 cells by CCK-8 method
|
[PMID: 38718626] |
USP10-IN-3 (compound D1) (0-100 µM) inhibits cell proliferation with an IC50 value of 2.3 µM for Huh-7 cells[1].
USP10-IN-3 (compound D1) (0-10 µM; 24 h) induces apoptosis and cell cycle arrest at S-phase in a dose-dependent manner[1].
USP10-IN-3 (compound D1) (0-30 µM; 24 h) decreases the expression of YAP1, p53, p21 in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Huh-7 cells
-
Concentration:0, 0.625, 1.25, 2.5, 5, 10 µM
-
Incubation Time:24 h
-
Result:Induced apoptosis in a dose-dependent manner.
-
Cell Line:Huh-7 cells
-
Concentration:0, 0.625, 1.25, 2.5, 5 µM
-
Incubation Time:24 h
-
Result:Induced cell cycle arrest at S-phase.
-
Cell Line:Huh-7 cells
-
Concentration:0, 0.37, 1.1, 3.3, 10, 30 µM
-
Incubation Time:24 h
-
Result:Decreased the expression of YAP1, p53, p21 in a dose-dependent manner.
Chemical Information
-
CAS. Nr. 3059565-11-3
-
Appearance Solid
-
Molecular Weight 512.99
-
Formel C29H25ClN4O3
-
Color White to off-white
-
SMILES
CC1=CC=C2C(C(C3=NC(C4=C(C=CC=C4)C)=NO3)=CN(C2=C1)CC(NCCC5=CC=C(C=C5)Cl)=O)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 5 mg/mL (9.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (278 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9494 mL | 9.7468 mL | 19.4936 mL | 48.7339 mL |
| 5 mM | 0.3899 mL | 1.9494 mL | 3.8987 mL | 9.7468 mL |
USP10-IN-3 Related Classifications
HY-163622 Related Classifications
Powered by Bioz