KAI-11101
KAI-11101 is the inhibitor for dual leucine zipper kinase (DLK, MAP3K12) with a Ki of 0.7 nM. KAI-11101 inhibits Paclitaxel (HY-B0015)-induced cJun phosphorylation (IC50=95 nM) and thus inhibits the activation of MAPK pathway. KAI-11101 is blood brain barrier penetrable and can be further investigated for its neuroprotective property.
For research use only. We do not sell to patients.
- Formula: C21H23F4N5O3
- Molecular Weight:469.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All MAP3K Isoforms
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Biological Activity
Chemical Information
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Molecular Weight 469.43
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Formula C21H23F4N5O3
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SMILES
O=C1C(N(CC)N=C2C3=CC(OC(F)F)=C(N)N=C3)=C2C=CN1[C@H]4[C@@H](OC)CC(F)(F)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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