Atevirdine
Based on 1 Customer Validation
Atevirdine is a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Atevirdine inhibits non-nucleoside reverse transcriptase that leads to viral multiplication.
For research use only. We do not sell to patients.
- Purity: 98.69%
- CAS No.: 136816-75-6
- Formula: C21H25N5O2
- Molecular Weight:379.46
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Storage:
-80°C
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Infection Compound Library
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HY-L215
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CEM-SS | EC50 |
10 x 10-4 μM
Compound: Atevirdine
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Antiviral activity against HIV infected in human CEM-SS cells assessed as inhibition of virus induced cell killing by XTT assay
Antiviral activity against HIV infected in human CEM-SS cells assessed as inhibition of virus induced cell killing by XTT assay
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[PMID: 19345581] |
| MT2 | CC50 |
>10 μM
Compound: 2
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Cytotoxic concentration against MT-2 cells
Cytotoxic concentration against MT-2 cells
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[PMID: 7684450] |
| MT2 | ED50 |
<0.2 μM
Compound: 2
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Inhibition of HIV-1 IIIB replication in MT2 (human lymphocyte) cells.
Inhibition of HIV-1 IIIB replication in MT2 (human lymphocyte) cells.
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[PMID: 7684450] |
| MT2 | IC50 |
1.59 μM
Compound: U-87201
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Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells
Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells
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[PMID: 7689109] |
| PBMC | CC50 |
>10 μM
Compound: 2
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Cytotoxic concentration against PBMC cells
Cytotoxic concentration against PBMC cells
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[PMID: 7684450] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 136816-75-6
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Appearance Solid
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Molecular Weight 379.46
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Formula C21H25N5O2
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Color White to light yellow
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SMILES
O=C(N1CCN(C2=NC=CC=C2NCC)CC1)C(N3)=CC4=C3C=CC(OC)=C4
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Shipping
Shipping with dry ice.
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Storage
-80°C
Solvent & Solubility
DMSO : 125 mg/mL (329.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6353 mL | 13.1766 mL | 26.3532 mL | 65.8831 mL |
| 5 mM | 0.5271 mL | 2.6353 mL | 5.2706 mL | 13.1766 mL | |
| 10 mM | 0.2635 mL | 1.3177 mL | 2.6353 mL | 6.5883 mL | |
| 15 mM | 0.1757 mL | 0.8784 mL | 1.7569 mL | 4.3922 mL | |
| 20 mM | 0.1318 mL | 0.6588 mL | 1.3177 mL | 3.2942 mL | |
| 25 mM | 0.1054 mL | 0.5271 mL | 1.0541 mL | 2.6353 mL | |
| 30 mM | 0.0878 mL | 0.4392 mL | 0.8784 mL | 2.1961 mL | |
| 40 mM | 0.0659 mL | 0.3294 mL | 0.6588 mL | 1.6471 mL | |
| 50 mM | 0.0527 mL | 0.2635 mL | 0.5271 mL | 1.3177 mL | |
| 60 mM | 0.0439 mL | 0.2196 mL | 0.4392 mL | 1.0981 mL | |
| 80 mM | 0.0329 mL | 0.1647 mL | 0.3294 mL | 0.8235 mL | |
| 100 mM | 0.0264 mL | 0.1318 mL | 0.2635 mL | 0.6588 mL |
Atevirdine Related Classifications
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