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Cat. No.: HY-144685

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ATM Inhibitor-2

ATM Inhibitor-2 (compound 7) is a potent and selective ATM inhibitor, with an IC₅₀ of <1 nM.

For research use only. We do not sell to patients.

CAS No.: 2769140-29-4
Formula: C₂₆H₃₁N₇O₃
Molecular Weight:489.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

ATM Inhibitor-2 Chemical Structure

CAS No.: 2769140-29-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ATM Inhibitor-2 (compound 7) is a potent and selective ATM inhibitor, with an IC₅₀ of <1 nM^[1].

IC₅₀ & Target

ATM

<1 nM (IC₅₀)

All ATM/ATR Isoforms :

Chemical Information

CAS No. 2769140-29-4
Molecular Weight 489.57
Formula C₂₆H₃₁N₇O₃
SMILES

CN(CCNC(NC1=CC=C(C=N1)C2=CC=C3N=CC4=C(N(C(N4C)=O)C5CCOCC5)C3=C2)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dimitrov T, et al. Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity. Eur J Med Chem. 2022 May 5;235:114234. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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ATM Inhibitor-2

All ATM/ATR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ATM Inhibitor-2 Related Classifications

HY-144685 Related Classifications