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Cat. No.: HY-153729

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ATR-IN-29

ATR-IN-29 is a potent and orally active ATR kinase inhibitor with an IC₅₀ value of 1 nM. ATR-IN-29 shows antiproliferative activity.

For research use only. We do not sell to patients.

CAS No.: 2761193-67-1
Formula: C₁₉H₂₂N₈O
Molecular Weight:378.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

ATR-IN-29 Chemical Structure

CAS No.: 2761193-67-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ATR-IN-29 is a potent and orally active ATR kinase inhibitor with an IC₅₀ value of 1 nM. ATR-IN-29 shows antiproliferative activity^[1].

IC₅₀ & Target^[1]

ATR

1 nM (IC₅₀)

All ATM/ATR Isoforms :

In Vitro

ATR-IN-29 (compound 1) (4 days) shows antiproliferative activity with IC₅₀s of 156.70, 38.81, 22.48, 181.60, 19.02 nM for A549, HCC1806, HCT116, OVCAR-3, NCI-H460 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ATR-IN-29 (10 mg/kg; p.o.; once) shows good pharmacokinetic parameters with t_1/2 of 1.64 h, C_max of 9343 ng/mL, AUC_0-t of 98507 ng·h/mL, AUC_0-inf of 98517 ng·h/mL in CD-1 (ICR) mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2761193-67-1
Molecular Weight 378.43
Formula C₁₉H₂₂N₈O
SMILES

CC1=C2N(N=C(N3[C@@H](COCC3)C)C=C2C4=CC=NN4C)C(C5=NNC=C5)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sui Xiong Cai, et al. Substituted imidazo[1,5-b]pyridazine compounds as kinase inhibitors and use thereof. WO2022135560A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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