2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. ATR-IN-29

ATR-IN-29 is a potent and orally active ATR kinase inhibitor with an IC50 value of 1 nM. ATR-IN-29 shows antiproliferative activity.

For research use only. We do not sell to patients.

ATR-IN-29 Chemical Structure

ATR-IN-29 Chemical Structure

CAS No. : 2761193-67-1

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ATR-IN-29 Related Antibodies

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Description

ATR-IN-29 is a potent and orally active ATR kinase inhibitor with an IC50 value of 1 nM. ATR-IN-29 shows antiproliferative activity[1].

IC50 & Target[1]

ATR

1 nM (IC50)

In Vitro

ATR-IN-29 (compound 1) (4 days) shows antiproliferative activity with IC50s of 156.70, 38.81, 22.48, 181.60, 19.02 nM for A549, HCC1806, HCT116, OVCAR-3, NCI-H460 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATR-IN-29 Related Antibodies
In Vivo

ATR-IN-29 (10 mg/kg; p.o.; once) shows good pharmacokinetic parameters with t1/2 of 1.64 h, Cmax of 9343 ng/mL, AUC0-t of 98507 ng·h/mL, AUC0-inf of 98517 ng·h/mL in CD-1 (ICR) mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

378.43

Formula

C19H22N8O
CAS No.
SMILES

CC1=C2N(N=C(N3[C@@H](COCC3)C)C=C2C4=CC=NN4C)C(C5=NNC=C5)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATR-IN-29 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATR-IN-292761193-67-1ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedInhibitorinhibitorinhibit

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ATR-IN-29
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HY-153729
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