2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. ATR-IN-31

ATR-IN-31 is a selective ATR kinase inhibitor with an IC50 of 7 nM. ATR-IN-31 does not significantly inhibit ATM kinase activity. ATR-IN-31 inhibits viability of prostate cancer cells.ATR-IN-31 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

ATR-IN-31

ATR-IN-31 Chemical Structure

CAS No. : 2954923-16-9

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ATR-IN-31 Related Antibodies

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Description

ATR-IN-31 is a selective ATR kinase inhibitor with an IC50 of 7 nM. ATR-IN-31 does not significantly inhibit ATM kinase activity. ATR-IN-31 inhibits viability of prostate cancer cells.ATR-IN-31 can be used for the research of prostate cancer[1].

IC50 & Target[1]

ATR

7 nM (IC50)

ATM

>10000 nM (IC50)

In Vitro

ATR-IN-31 (compound M3) potently inhibits purified ATR kinase activity with an IC50 of 7 nM[1].
ATR-IN-31 (compound M3) does not significantly inhibit purified ATM kinase activity, with an IC50 >10000 nM[1].
ATR-IN-31 (compound M3) inhibits purified DNA-PK kinase activity with an IC50 of 179.6 nM[1].
ATR-IN-31 (compound M3) (0-50 μM; 120 h) potently inhibits 22Rv1 human prostate cancer cell viability with an IC50 of 0.21 μM after 120 h of treatment[1].
ATR-IN-31 (compound M3) (2.0 nM) has high stability in human liver microsomes, with a half-life of 154.32 minutes[1].
ATR-IN-31 (compound M3) (2.0 nM) has moderate stability in mouse liver microsomes, with a half-life of 67.77 minutes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATR-IN-31 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Cmax AUC0-24
Mice[1] 10 mg/kg p.o. 2.0193 h 2924 ng/mL 9028 ng·h/mL
Molecular Weight

467.53

Formula

C25H25N9O
CAS No.
SMILES

CC1=C(C2=CC(N3CC4OC(CC4)C3)=NC5=C(C6=NNC=C6)C=NN52)C(C)=NN1C7=CC=CN=C7
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATR-IN-31 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATR-IN-312954923-16-9ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedprostate cancer cellsmouse liver microsomeshuman liver microsomes22Rv1 human prostate cancer cellATM kinaseATR kinaseprostate cancerDNA-PK kinaseInhibitorinhibitorinhibit

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