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Cat. No.: HY-172247

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ATR-IN-31

ATR-IN-31 is a selective ATR kinase inhibitor with an IC₅₀ of 7 nM. ATR-IN-31 does not significantly inhibit ATM kinase activity. ATR-IN-31 inhibits viability of prostate cancer cells.ATR-IN-31 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 2954923-16-9
Formula: C₂₅H₂₅N₉O
Molecular Weight:467.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ATR-IN-31 Chemical Structure

CAS No.: 2954923-16-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

ATR

7 nM (IC₅₀)

ATM

>10000 nM (IC₅₀)

All ATM/ATR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	216 nM Compound: 19a	Antiproliferative activity against human 22Rv1 cells incubated for 120 hrs by Cell-titer Glo luminescent assay Antiproliferative activity against human 22Rv1 cells incubated for 120 hrs by Cell-titer Glo luminescent assay	[PMID: 40029060]

In Vitro

ATR-IN-31 (compound M3) potently inhibits purified ATR kinase activity with an IC₅₀ of 7 nM^[1].
ATR-IN-31 (compound M3) does not significantly inhibit purified ATM kinase activity, with an IC₅₀ >10000 nM^[1].
ATR-IN-31 (compound M3) inhibits purified DNA-PK kinase activity with an IC₅₀ of 179.6 nM^[1].
ATR-IN-31 (compound M3) (0-50 μM; 120 h) potently inhibits 22Rv1 human prostate cancer cell viability with an IC₅₀ of 0.21 μM after 120 h of treatment^[1].
ATR-IN-31 (compound M3) (2.0 nM) has high stability in human liver microsomes, with a half-life of 154.32 minutes^[1].
ATR-IN-31 (compound M3) (2.0 nM) has moderate stability in mouse liver microsomes, with a half-life of 67.77 minutes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	AUC_0-24
Mice^[1]	10 mg/kg	p.o.	2.0193 h	2924 ng/mL	9028 ng·h/mL

Chemical Information

CAS No. 2954923-16-9
Molecular Weight 467.53
Formula C₂₅H₂₅N₉O
SMILES

CC1=C(C2=CC(N3CC4OC(CC4)C3)=NC5=C(C6=NNC=C6)C=NN52)C(C)=NN1C7=CC=CN=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fei xiao, et al. New type pyrazolopyrimidine compound and composition thereof, preparation method therefor and use thereof. WO2023138343A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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