RO 4938581
Based on 1 Customer Validation
RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 883093-10-5
- Formula: C13H8BrF2N5
- Molecular Weight:352.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Ki: 4.6 nM (GABAA α5β3γ2a), 174 nM (GABAA α1β3γ2a), 185 nM (GABAA α2β3γ2a), 80 nM (GABAA α3β3γ2a)[1]
RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 883093-10-5
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Appearance Solid
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Molecular Weight 352.14
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Formula C13H8BrF2N5
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Color White to off-white
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SMILES
FC(C1=C2N(C3=CC=C(Br)C=C3C4=NC=NN4C2)C=N1)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (283.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8398 mL | 14.1989 mL | 28.3978 mL | 70.9945 mL |
| 5 mM | 0.5680 mL | 2.8398 mL | 5.6796 mL | 14.1989 mL | |
| 10 mM | 0.2840 mL | 1.4199 mL | 2.8398 mL | 7.0994 mL | |
| 15 mM | 0.1893 mL | 0.9466 mL | 1.8932 mL | 4.7330 mL | |
| 20 mM | 0.1420 mL | 0.7099 mL | 1.4199 mL | 3.5497 mL | |
| 25 mM | 0.1136 mL | 0.5680 mL | 1.1359 mL | 2.8398 mL | |
| 30 mM | 0.0947 mL | 0.4733 mL | 0.9466 mL | 2.3665 mL | |
| 40 mM | 0.0710 mL | 0.3550 mL | 0.7099 mL | 1.7749 mL | |
| 50 mM | 0.0568 mL | 0.2840 mL | 0.5680 mL | 1.4199 mL | |
| 60 mM | 0.0473 mL | 0.2366 mL | 0.4733 mL | 1.1832 mL | |
| 80 mM | 0.0355 mL | 0.1775 mL | 0.3550 mL | 0.8874 mL | |
| 100 mM | 0.0284 mL | 0.1420 mL | 0.2840 mL | 0.7099 mL |
RO 4938581 Related Classifications
HY-107489 Related Classifications
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