Denecimig
Based on 1 Customer Validation
Denecimig (Mim8) is a factor VIII-mimetic bispecific antibody with micromolar human binding affinity for Factor X and Factor IXa. Denecimig binds Factor X and Factor IXa, localizes both to the phospholipid surface, enhances the Factor IXa-mediated activation of Factor X to Factor Xa, and stimulates the proteolytic activity of Factor IXa via its monovalent anti-Factor IXa arm. Denecimig is applicable to research related to hemophilia A.
For research use only. We do not sell to patients.
- Purity : 95.90%
- CAS No.: 2488745-86-2
- Molecular Weight:145.46 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
F9 & F10
In Vitro
Denecimig efficiently enhances FX activation by localizing FIXa and FX to phospholipid surfaces, with its anti-FIXa arm alone increasing FIXa proteolytic activity 15,000-fold, and binds FIXa and FX with micromolar dissociation constants[1].
Denecimig (0.1-1000 nM) normalizes thrombin generation in congenital HA plasma with 15-fold greater potency than emicizumab[1].
Mim8 exhibits procoagulant activity in hemophilia A-like blood that is ~13-fold more potent than a sequence identical analog of emicizumab, as measured by peak thrombin generation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Denecimig (Mim8) (up to 3 mg/kg/wk; weekly; 26 weeks) reduces bleeding in cynomolgus monkey hemophilia A models and demonstrates potent pharmacodynamic effects and a favorable safety profile[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 kappa
Application
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2488745-86-2
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Appearance Liquid
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Molecular Weight 145.46 kDa
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Color Colorless to light yellow
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SMILES
[Denecimig]
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Synonyms
Mim8
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Denecimig Related Classifications
HY-P990060 Related Classifications
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